Original ArticlesClinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes☆
Section snippets
Methods
The records of the L. F. Montgomery Ophthalmic Pathology Laboratory, Emory University, were searched for the year 1996 for surgically excised subfoveal choroidal neovascularization specimens. The technique for surgical removal has been previously described.21 The surgeons attempted to remove the choroidal neovascularization intact and lay the external side (choroid side) of the specimen down on a surgical sponge. The choroidal neovascularization specimens were fixed in 10% neutral buffered
Results
Thirty surgically excised choroidal neovascularization specimens from 30 eyes eligible for this study were accessioned in 1996. Of the 30 specimens, three were histologically classified as type 1, seven as type 2, and five as combined; 15 could not be histologically classified with regard to orientation due to artifactual folding and redundancy. Therefore, 10 eyes of 10 patients had subfoveal choroidal neovascularization (three, type 1; seven, type 2) eligible for the study. The results of
Discussion
The advent of submacular surgery has enabled clinicopathologic correlation, including fluorescein angiography, at relatively early stages in the evolution of choroidal neovascular membranes. Examination of the excised neovascular membranes from patients with different underlying diseases has been described.24., 25., 26., 27., 28., 29. The cellular and extracellular components of the membranes, including retinal pigment epithelium, vascular endothelium, fibrocytes, macrophages, photoreceptors,
Acknowledgements
The authors wish to thank Drs Thomas M. Aaberg, Sr, Robert Bergen, Logan Brooks, Antonio Capone, Jr, David d’Heurle, William Hagler, Michael Jacobson, Jerome Magolan, Daniel F. Martin, Philip Martin, David Saperstein, Paul Sternberg, Jr, and William Wood for submitting specimens, and Mr James Gilman for providing illustrations.
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Supported in part by departmental core grant no. EY06030 from the National Institutes of Health, Bethesda, Maryland, and an unrestricted departmental grant from Research to Prevent Blindness, Inc, New York, New York.