Local synthesis of apolipoprotein J in the eye
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Cited by (25)
Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results
2018, Ocular SurfaceCitation Excerpt :Shedding and lysis of apical epithelial cells also contribute to the tear protein profile [42]. CLU mRNA is expressed throughout the corneal epithelium, but the protein product is found in humans [12–14,59] and mice [10] only in the apical cell layers. When these mucosal epithelial cells undergo squamous metaplasia in dry eye, CLU protein is depleted [60].
Clusterin in the eye: An old dog with new tricks at the ocular surface
2016, Experimental Eye ResearchCitation Excerpt :The first publication on CLU in the eye was in 1992, describing elevated CLU expression in the degenerative disorder, retinitis pigmentosa (Jones et al., 1992). CLU expression in various parts of the eye was subsequently documented in developmental studies in rats (Ahuja et al., 1994) and mice (Reeder et al., 1995), including in the lens, cornea and ciliary body, and CLU protein was demonstrated in the aqueous and vitreous of the mature human eye (Reeder et al., 1995). A number of studies at that time investigated a role for CLU in retinal degenerative disease.
Clusterin in neurological disorders: Molecular perspectives and clinical relevance
2012, Brain Research BulletinCitation Excerpt :However, recent studies suggest that in animal models of peripheral neuropathies, such as experimental autoimmune neuritis, subcutaneous administration of recombinant clusterin promotes re-myelination, improvement in neurophysiological and pathological signs [31]. Several lines of evidence suggest that eye tissues (e.g., ciliary body, cornea, lens, retina, vitreous, etc.) of various mammalian species express clusterin mRNA and clusterin protein [57,126,138,149,163]. Additionally, cone photoreceptor cells express clusterin-like protein showing 25% identity with clusterin [148,172].
Clusterin in human corneal endothelium and aqueous humor
1999, Experimental Eye ResearchRetinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles
1997, Molecular Brain ResearchThe Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing
2023, International Journal of Molecular Sciences