Optic nerve head axonal transport in rabbits with hereditary glaucoma*
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Diagnosis and treatment of glaucoma in client-owned rabbits (Oryctolagus cuniculus): 16 eyes from 11 rabbits (2008-2019)
2020, Journal of Exotic Pet MedicineCitation Excerpt :Device-dependent reference ranges for IOP have been established in rabbits, with a mean IOP of 9.51 ± 2.62 mmHg using the Tonovet (after calibration in ‘p’ mode), and 15.44 ± 2.16 mmHg using the Tono-Pen Avia [21]. In rabbits with congenital glaucoma, IOPs have been reported to reach 26-48 mmHg at the time of diagnosis [22]. Gonioscopy is the diagnostic examination of the filtration angle with a gonioscopic lens [1].
Biomechanical aspects of axonal damage in glaucoma: A brief review
2017, Experimental Eye ResearchCitation Excerpt :This species is more accessible and easier to breed and house than monkeys, and has considerable larger eyes than rats or mice, a fact that facilitates experimental procedures. Rabbits with hereditary congenital glaucoma and optic nerve damage in response to high IOP have been characterized (Bunt-Milam et al., 1987a, b). At the ONH, a poorly developed LC has been described with some connective tissue beams that radiate from the central retinal vessels to the optic nerve sheath (Flage, 1977).
Establishment of the ocular hypertension model using the common marmoset
2013, Experimental Eye ResearchCitation Excerpt :Increasing attention is being paid to evaluating the appearance of the optic nerve head and peripapillary retina in the diagnosis of glaucoma, especially in its early stage. Glaucoma pathology has been extensively studied at the level of the retinal ganglion cells (RGC) and optic nerve using rodents (mice, rats, and rabbits) (Aihara et al., 2003; Bunt-Milam et al., 1987; McKinnon et al., 2002) and non-human primates [mainly macaque monkeys such as rhesus (Macaca mulatta) and cynomolgus monkeys (Macaca fascicularis)] (Quigley and Hohman, 1983). Rodents such as mice, rats, and rabbits are most commonly used in basic research into glaucoma and drug screening (Hare et al., 2001), because they are small and easy to handle and low cost, and transgenic animals are readily available.
Regeneration of retinal ganglion cell axons in organ culture is increased in rats with hereditary buphthalmos
2007, Experimental Eye ResearchCitation Excerpt :Hereditary animal models of glaucoma with slowly but chronically developing elevated IOP offer the opportunity to analyze RGCs at different stages of the disease. Models of chronic glaucoma include pigment dispersion glaucoma in the DBA/2 mouse (Chang et al., 1999; John et al., 1998), and buphthalmic rabbits (Bunt-Milam et al., 1987), beagles (Gelatt, 1977), and rats (Addison and How, 1926; Heywood, 1975; Young et al., 1974). However, no rat strain with a high incidence of buphthalmos has yet been bred for use in biomedical research (Goldblum and Mittag, 2002).
Correlation between retinal ganglion cell death and chronically developing inherited glaucoma in a new rat mutant
2004, Experimental Eye ResearchUltrastructural alterations in the aqueous outflow pathway of adult buphthalmic rabbits
1991, Experimental Eye Research
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This work was supported by NIH Research Grants EY-01311, -02726 and -01730, and RR-01203, and in part by an unrestricted grant from Research to Prevent Blindness, Inc. Dr Bunt-Milam is a recipient of the William and Mary Greve International Research Scholar Award from Research to Prevent Blindness, Inc.