Light-evoked oxygen responses in the isolated toad retina
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Cited by (26)
Extracellular K<sup>+</sup> reflects light-evoked changes in retinal energy metabolism
2022, Experimental Eye ResearchCitation Excerpt :Light of high scotopic intensity can suppress 2/3 of the rod photoreceptor dark current, which leads to saving about one hundred million ATP molecules per second. While there are other light-dependent changes in metabolism in the outer retina (Ames et al., 1992; Haugh-Scheidt et al., 1995; Okawa et al., 2008), the dominant one is the change in pumping of Na+ and K+. The energy production in the rod decreases to satisfy this lowered energy demand, and consequently consumption of O2 by the rod decreases, and PO2 near the inner segment of the rod (the location of the cell mitochondria) increases (e.g. (Linsenmeier and Braun, 1992)).
Retinal oxygen: from animals to humans
2017, Progress in Retinal and Eye ResearchCitation Excerpt :The Ca+2 is eliminated by a Na+/Ca++ exchanger in the outer segment, which brings in more Na+, so the metabolic load due to Ca+2 entry is all transferred to the need to pump Na+.) The second metabolic change is an increase in QO2 during illumination (Ames et al., 1992; Haugh-Scheidt et al., 1995a; Kimble et al., 1980), because there is more turnover of cGMP in light (Dawis et al., 1988; Goldberg et al., 1983), which uses more GTP. It is difficult to measure the absolute magnitude of the pump and cyclic nucleotide components, partly because there are other illumination-independent processes that use energy, and partly because trying to block one process could influence the other.
Retinal energy metabolism
2010, Ocular Disease: Mechanisms and Management Expert ConsultRetinal energy metabolism
2010, Ocular Disease: Mechanisms and ManagementOxygen consumption in the isolated toad retina
1995, Experimental Eye Research
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Present address: Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine 1855 West Taylor Street, Chicago, IL 60612, U.S.A.