Elsevier

Survey of Ophthalmology

Volume 41, Issue 3, November–December 1996, Pages 215-228
Survey of Ophthalmology

Current research
Prognostic parameters in uveal melanoma: a review

https://doi.org/10.1016/S0039-6257(96)80024-5Get rights and content

Abstract

Histologic cell type, largest tumor diameter and tumor location have traditionally been regarded as the leading predictors of survival for uveal melanoma. Morphological cell typing is, however, subjective to variations in interpretation. More objective classification parameters have emerged from extensive cytomorphometrical and DNA flow cytometrical studies. For patients with uveal melanoma there is no effective therapy if metastases have developed, and the median survival after clinical diagnosis of hepatic metastases is extremely poor. Current research focuses on the mechanisms underlying the metastatic process, including tumor vasculature, cytogenetics, oncogene activation, immunology, melanoma-associated antigens and tumor cell migration (cell-cell and cell-matrix interaction). Several new prognostic parameters have emerged from these studies, such as closed vascular patterns, loss of one chromosome 3, and different indices of cell proliferation. Furthermore, considerable genotypical and phenotypical differences have been found between uveal and cutaneous melanoma. In prospective studies on large series of melanomas a combination of histopathological and/or clinical prognostic parameters might be selected with high sensitivity and specificity, providing a way of selecting patients at high risk of developing metastatic disease, who might be eligible for adjuvant therapy.

References (137)

  • CA Griffin et al.

    Trisomy 6p in ocular melanoma

    Cancer Genet Cytogenet

    (1988)
  • DE Horsman et al.

    Monosomy 3 and isochrome 8Q in a uveal melanoma

    Cancer Genet Cytogenet

    (1990)
  • T Hunter

    Cooperation between oncogenes

    Cell

    (1991)
  • A Huntington et al.

    A simple cytological method for predicting the malignant potential of intraocular melanoma

    Pathol Res Pract

    (1989)
  • MJ Jager et al.

    Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation

    Am J Ophthalmol

    (1988)
  • CE Klein et al.

    Identification of a melanoma progression antigen as integrin VLA-2

    Invest Dermatol

    (1991)
  • GPM Luyten et al.

    No effect of pre-enucleation irradiation on survival of patients with uveal melanoma

    Am J Ophthalmol

    (1995)
  • DM Marcus et al.

    The value of nucleolar organizer regions in uveal melanoma

    Am J Ophthalmol

    (1990)
  • J McCurdy et al.

    A simple, efficient and reproducible method for estimating the malignant potential of uveal melanoma from routine H & E slides

    Pathol Res Pract

    (1991)
  • IW McLean et al.

    Choroidal-ciliary body melanoma. A multivariate survival analysis of tumor location

    Ophthalmology

    (1995)
  • IW McLean et al.

    Modifications of Callender's classification of uveal melanoma at the Armed Forces Institute of Pathology

    Am J Ophthalmol

    (1983)
  • IW McLean et al.

    Reappraisal of Callender's spindle A type of malignant melanoma of choroid and ciliary body

    Am J Ophthalmol

    (1978)
  • CM Mooy et al.

    Ki-67 Immunostaining in uveal melanoma: the effect of pre-enucleation radiotherapy

    Ophthalmology

    (1990)
  • CM Mooy et al.

    Neural cell adhesion molecule distribution in primary and metastatic uveal melanoma

    Hum Pathol

    (1995)
  • GJ Adema et al.

    Melanocytic lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA

    Am J Pathol

    (1993)
  • IA Akslen et al.

    Expression of p53 protein in cutaneous melanoma

    Int J Cancer

    (1992)
  • SM Albeda et al.

    Integrin distribution in malignant melanoma: association of the β3 subunit with tumor progression

    Cancer Res

    (1990)
  • PJM Berge ten et al.

    Integrines expression in uveal melanoma differs from cutaneous melanoma

    Invest Ophthalmol Vis Sci

    (1993)
  • E Bock

    Cell-cell adhesion molecules

    Biochem Soc Trans

    (1991)
  • FT Bosman

    Integrins: cell adhesives and modulators of cell function. Review

    Histochem J

    (1993)
  • MN Burnier et al.

    Immunohistochemical evaluation of uveal melanocytic tumors. Expression of HMB-45, S-100 protein, and neuron-specific enolase

    Cancer

    (1991)
  • GR Callender

    Malignant melanotyc tumors of the eye: A study of histologic types in 111 cases

    Trans Am Acad Ophthalmol Otolaryngol

    (1931)
  • S Carrel et al.

    Surface antigenic profile of uveal melanoma lesions analysed with a panel of monoclonal antibodies directed against cutaneous melanoma

    Anticancer Res

    (1990)
  • DH Char et al.

    Fine needle aspiration in uveal melanoma

    Acta Cytologica

    (1989)
  • TC Chen et al.

    Flow cytometry measurements of nuclear RNA content in uveal melanoma

    Ophthalmic Res

    (1990)
  • G Chevenix-Trench et al.

    Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p-53

    Oncogene

    (1990)
  • K Coleman et al.

    Syntactic structure analysis in uveal melanomas

    Br J Ophthalmol

    (1994)
  • K Coleman et al.

    Prognostic factors following enucleation of 111 uveal melanomas

    Br J Ophthalmol

    (1993)
  • DW Cottam et al.

    Regulation of matrix metalloproteinases their role in tumor invasion and metastasis

    Int J Oncol

    (1993)
  • DW Cottam et al.

    Degradative enzyme expression in uveal melanoma

    Invest Ophthalmol Vis Sci

    (1992)
  • DW Cottam et al.

    Cytokine modulation of gelatinase expression in a series of human melanoma cell lines

    Cytokine

    (1991)
  • DW Cottam et al.

    Gelatinolytic metalloproteinase secretion patterns in ocular melanoma pattern

    Invest Ophthalmol Vis Sci

    (1992)
  • NJ Crowley et al.

    Late recurrence of malignant melanoma

    Ann Surg

    (1990)
  • PO de la Cruz et al.

    Lymphocytic infiltration in uveal malignant melanoma

    Cancer

    (1990)
  • R Dahlenfors et al.

    Cytogenetical observations in nine ocular malignant melanomas

    Anticancer Res

    (1993)
  • BE Damato et al.

    Monoclonal antibodies to uveal melanomas

    Eye

    (1987)
  • EHJ Danen et al.

    Emergence of α5β1 fibronectin- and αvβ3 vitronectin-receptor expression in melanocytic tumour progression

    Histopathology

    (1994)
  • K Dan et al.

    Plasminogen activators, tissue degradation and cancer

    Adv Cancer Res

    (1985)
  • I De Waard-Siebinga et al.

    Establishment and characterization of an uveal melanoma cell line

    Int J Cancer

    (1995)
  • I De Waard-Siebinga et al.

    HLA expression and tumor-infiltrating immune cells in uveal melanoma

    Graefe's Arch Clin Exp Ophthalmol

    (1996)
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