Elsevier

The Lancet

Volume 351, Issue 9118, 13 June 1998, Pages 1783-1784
The Lancet

Research Letters
Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin-like growth factor I

https://doi.org/10.1016/S0140-6736(98)24024-4Get rights and content

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  • Immune regulation of the ocular surface

    2022, Experimental Eye Research
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    Substance P (SP) is one of the major neuropeptides constitutively secreted by nerve endings in the normal cornea, and a physiological level of SP is required for corneal epithelial homeostasis (Yamada et al., 2002, 2003; Suvas, 2017). Complete abrogation of SP function by genetically knocked-out NK1R, the preferred SP receptor, has been shown to cause loss of corneal epithelial cells (Gaddipati et al., 2016), and topical treatment with SP-derived peptide in neurotrophic keratopathy, a corneal disease characterized by impaired corneal nerve function which may lead to decreased SP production at the ocular surface, has been shown to promote the closure of the corneal epithelial defect (Chikama et al., 1998). However, the protective roles of SP can be overturned when there is an excessive amount of SP at the ocular surface that is higher than the physiological level, primarily through promoting corneal resident APC maturation and mobilization, recruiting peripheral leukocytes to infiltrate the cornea, and inducing corneal neovascularization directly on parent vessels and indirectly through activating innate immune cells including mast cells to secret VEGF-A, all of which finally leads to neurogenic inflammation and propagation of an inflammatory cascade, as reported in DED and corneal injuries (Yu et al., 2020; Chao et al., 2015; Ziche et al., 1990; Bignami et al., 2014; Green et al., 2019; Liu et al., 2020; Barbariga et al., 2018; Cho et al., 2020; Sahu et al., 2018).

  • Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases

    2022, Experimental Eye Research
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    Substance P promotes wound healing in injured cornea and induces nerve fibre regeneration to restore corneal sensitivity (Yang et al., 2014). Application of eye drops containing substance P and insulin-like growth factor-1 restored corneal wound healing in a rat model of neurotrophic keratopathy (Nagano et al., 2003), and a human subject (Chikama et al., 1998). Substance P combined with insulin-like growth factor-1 also promotes the rate of epithelial healing after photorefractive keratectomy (Ghiasi et al., 2018).

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