Original ArticlesPrevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes☆
Section snippets
Study design
Details of the study design have been previously reported.10, 11, 12, 13 This study was approved by the institute research board of the School of Medicine, University of California San Diego. Two hundred four patients (237 eyes; 171 patients with unilateral holes and 33 patients with bilateral holes) with full-thickness macular holes, including both centrally and eccentrically located stage II, III, and IV macular holes, were recruited from 16 community and university-based ophthalmology
Prevalence of ERM at the baseline examination
At the baseline examination, ERM were detected in 145 of 224 eyes, resulting in an overall prevalence rate of 65%. Of the 224 study eyes, 20 eyes had a posterior chamber intraocular lens implant (4 eyes with stage II macular holes, 16 eyes with stage III/IV macular holes). The prevalence rate of ERM for the 20 pseudophakic eyes was 80% (16 eyes); the prevalence rate of ERM for the 204 phakic eyes was 63% (129 eyes), P = 0.10 by Fisher’s exact test. Pseudophakic eyes tended to have more severe
Discussion
It has been established that ERM may be associated with macular holes. However, the relationship of membranes to the pathophysiology of the disease and to surgical treatment remains unclear. The purpose of our study was to determine the prevalence and correlates of ERM in macular holes in the VMHS and to characterize the natural history of ERM formation observed in eyes with macular holes that were randomly assigned to observation.
Although other clinical studies of macular holes have reported
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Cited by (40)
Idiopathic Epiretinal Membrane and Vitreomacular Traction
2016, OphthalmologyMacular Hole
2012, Retina Fifth EditionIdiopathic Full-Thickness Macular Holes and the Vitreomacular Interface: A High-Resolution Spectral-Domain Optical Coherence Tomography Study
2012, American Journal of OphthalmologyCitation Excerpt :This may lead centrifugally to disruption of the remaining outer photoreceptor layer.53 However, it is impossible to determine whether the MH occurred before the epiretinal membrane developed or developed as a complication of the tangential traction of the membrane, because moderate epiretinal membranes often accompany stage 3 and 4 MHs at the initial diagnosis.54,55 Second, we did not determine if the differences in the vitreomacular interfaces in idiopathic full-thickness MHs were associated with the postoperative visual prognosis.
Macular hole surgery
2011, Ophthalmic Surgery: Principles and Practice Expert ConsultUltrastructure of the Vitreomacular Interface in Full-Thickness Idiopathic Macular Holes: A Consecutive Analysis of 100 Cases
2006, American Journal of OphthalmologyCitation Excerpt :Our data revealed cellular or fibrocellular proliferation in 57 of 100 cases. In the Vitrectomy for Macular Hole Study, 65% of patients with idiopathic macular holes showed cellular proliferation in stereoscopic examination of fundus photographs.19 Guyer and associates14 reported on a higher incidence (73%) of epiretinal tissue surrounding macular holes in a histopathologic study of 22 postmortem eyes with full-thickness macular holes.
Prevalence of full-thickness macular holes in urban and rural adult Chinese: The Beijing Eye Study
2006, American Journal of Ophthalmology
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Supported in part by NIH EYO 7366 (WRF), the Core Grant for Vision Research NIH NEI-EYO 3040 (SPA), and a grant from Alcon Inc, Fort Worth, Texas.
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Members of the Vitrectomy for Macular Hole Study Group are listed in the at the end of this article.