Correlation between static automated and scanning laser entoptic perimetry in normal subjects and glaucoma patients

doi:10.1016/S0161-6420(00)00248-7

Ophthalmology

Volume 107, Issue 9, September 2000, Pages 1693-1701

https://doi.org/10.1016/S0161-6420(00)00248-7 Get rights and content

Abstract

Objective

To compare the effectiveness of scanning laser entoptic perimetry with static automated perimetry as a noninvasive instrument for screening for glaucomatous damage in visually asymptomatic subjects within the central 60° (diameter) of vision.

Design

A masked cross-sectional study comparing entoptic perimetry to achromatic threshold perimetry.

Participants

Twenty-three subjects and controls from the Sharp Rees-Stealy Hospital and the Shiley Eye Center at the University of California, San Diego.

Testing

Virtual reality–based entoptic perimetry was compared with achromatic threshold perimetry.

Main outcome measures

For each testing session, we compared the presence of a disturbance in the entoptic perimetry stimulus with the presence of defects in visual function as measured by Humphrey automated visual field perimetry.

Results

Scanning laser entoptic perimetry reasonably estimates the overall visual field loss for moderate-to-severe scotomas as measured by the pattern deviation in standard visual field perimetry. Scanning laser entoptic perimetry has a sensitivity from 27% to 90% and a specificity from 50% to 100% for screening moderate-to-severe visual field defects caused by glaucoma within the central 60° diameter of vision.

Conclusions

Scanning laser entoptic perimetry may be an effective and inexpensive screening test in hospitals and community clinics for diagnosing visual field loss caused by glaucoma.

Section snippets

Subjects

A total of 16 glaucoma subjects (29 eyes, because 3 were too impaired) and 7 normal subjects (12 eyes) were recruited from local eye clinics. A total of 41 eyes were tested using both standard Humphrey automated visual field perimetry (SAP) and scanning laser entoptic perimetry. All patients had previously undergone multiple Humphrey Field Analyzer tests for all eyes as part of their routine examination protocol using the Humphrey Field Anaylzer protocol 30-2. All glaucoma subjects were

Results

There were 29 glaucomatous eyes included in the study. All 29 eyes had abnormalities on SAP, and 19 of these eyes reported entoptic perimetry disturbances. None of the 12 normal eyes had abnormalities on either SAP or entoptic perimetry. An example of an entoptic tracing and an SAP printout appear in Figure 2. Average testing time for entoptic perimetry per eye was 30 seconds.

Discussion

Our previous studies with entoptic perimetry have suggested that entoptic perimetry would be useful in screening subjects who have absolute or near-absolute scotomas caused by retinal damage from a variety of pathologic conditions (e.g., cytomegalovirus retinitis, ocular melanoma, age-related macular degeneration). Although several studies examine how well entoptic perimetry can detect scotomas caused by glaucoma (e.g.,4), to our knowledge no study to date has implemented testing using a

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^☆: Supported by NIH grant NEI EY11961 (DJP), NIH grant NEI EY07366 (WRF), Core Grant for Vision Research NEI EY-03040 (SPA, LLB), and a departmental grant from Research to Prevent Blindness (WRF).

View full text

Correlation between static automated and scanning laser entoptic perimetry in normal subjects and glaucoma patients☆

Abstract

Objective

Design

Participants

Testing

Main outcome measures

Results

Conclusions

Section snippets

Subjects

Results

Discussion

Am J Ophthalmol

Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis

Arch Ophthalmol

The utility of entoptic perimetry as a screening test for cytomegalovirus retinitis

Arch Ophthalmol

Rauschfeldkampimetrie

Eine neuartige perimetrische Untersuchungsweise. Klin Monatsbl Augenheilkd