Successful treatment with 5-fluorouracil of conjunctival intraepithelial neoplasia refractive to mitomycin-C1 Historical image
Section snippets
Case report
A 64-year-old-male patient presented with discomfort in his left eye of several years duration. The visual acuity was 20/30 and intraocular pressure was normal in this eye. Slit-lamp examination showed a slightly elevated, gelatinous lesion involving 210° of the limbus in the left eye (Fig 1). A superficial keratopathy was also noted. Impression cytology showed dysplastic epithelial cells and limbal stem cell deficiency. Multiple map biopsies revealed that the tumor had extended to the
Discussion
The primary treatment for CIN is surgical excision because histopathologic documentation of the diagnosis should be made.1, 3 When the tumor is diffuse, as in our patient, the recurrence rate is high.3 Even with negative findings at the excision borders, recurrence may occur.2, 3, 15 When the tumor is large, reconstruction is necessary. Lesions involving more than 50% of the corneal limbus tend to have poor prognosis after excision because of conjunctivalization.1, 16 In our case, limbal
Acknowledgements
The authors thank Professor Yozo Miyake, Department of Ophthalmology, Nagoya University School of Medicine, Japan, for invaluable suggestions during the preparation of the article.
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The authors have no financial interests in the products or devices mentioned in this article.