Original articleCataract surgery and the 5-year incidence of late-stage age-related maculopathy: Pooled findings from the Beaver Dam and Blue Mountains eye studie☆
Section snippets
Methods
Both the BDES and the BMES are population-based cohort studies of vision and common eye diseases in older, predominantly white populations. The baseline survey methods and procedures of these two cohort studies have been previously described.6, 10, 31, 32 Signed informed consent was obtained from all participants in each study.
The BDES, conducted from 1988 to 1990 in Beaver Dam, Wisconsin, examined 4926 of 5924 eligible residents aged 43 to 86 years (83.1% response). At the time of 5-year
Results
The combined cohort from the two studies consisted of 6019 persons (3684 from the BDES and 2335 from the BMES), including 3435 women and 2584 men. Table 1 shows that the age and gender distributions of the two samples were similar.
After excluding 100 eyes with either late-stage ARM lesion at baseline (67 eyes from the BDES and 33 eyes from the BMES) and eyes with missing or ungradable photographs at either examination, 11,393 eyes (5673 right, 5720 left) were considered at risk for the
Discussion
This analysis includes pooled data from two large population-based cohorts that employed similar diagnostic criteria and study methods. Our findings suggest that the 5-year risk for development of late-stage ARM in the operated eyes of older persons after cataract surgery may be two to five times the risk observed in phakic subjects with similar age, gender, and smoking characteristics. Almost all eyes that developed late-stage ARM during the 5-year period had some early-stage ARM lesions at
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Cataract Surgery and the Risk of Developing Late Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 Report Number 27
2022, OphthalmologyCitation Excerpt :Population-based longitudinal studies—the BDES and the Blue Mountains Eye Study (BMES)—in contrast to our results, found that the risk of developing late AMD increased after cataract surgery. The pooled results of the BDES and BMES found that a history of cataract surgery at baseline was associated with an increased incidence of late AMD at 5 years with an OR of 5.7 (95% CI, 2.4–13.6).11 The risk of AMD progression in eyes that received cataract surgery before the baseline visit persisted at 10 years with a risk ratio of 3.81 (95% CI, 1.89–7.69) for BDES and 3.3 (1.1–9.9) for BMES.9,12
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Manuscript no. 220409.
Supported by the National Institutes of Health (grant EY06594), the Australian National Health & Medical Research Council, Canberra (grants 974159 and 211069), and the Ophthalmic Research Institute of Australia.