Elsevier

Ophthalmology

Volume 86, Issue 9, September 1979, Pages 1662-1678
Ophthalmology

Ultrasonically Guided Needle Biopsy and Cytologic Diagnosis of Solid Intraocular Tumors*

https://doi.org/10.1016/S0161-6420(79)35349-0Get rights and content

Abstract

Six solid intraocular tumors were reliably diagnosed by needle biopsies and cytologic examination of the aspirates. All of the tumors had an unusual clinicalor diagnostic feature that raised the possibility of a non-melanomatous tumor. Two intraocular lesions that were obscured by opaque media or a retinal detachment were successfully biopsied under B-scan ultrasonographic guidance of the needle. Cytodiagnosis of narrow spindle B, plump spindle B, and epithelioid cell types, as well as one case of Coats' disease, was possible and correlated closely with the predominant cell types comprising the lesions discovered on histopathologic examination of the globes that were enucleated. The ocular tissues were not significantly disturbed and hemorrhage was not a serious problem. Details of the biopsy and cytologic techniques, the major clinical indications for the procedure, and the authors' belief that the procedure is not likely to produce local seeding or extraocular metastasis in cases of melanoma are presented and discussed. Considerable profit may attend the use of this technique for the diagnosis of possible metastatic lesions and tumors of the ciliary body. The technique, however, should not be routinely employed and should be restricted to extremely difficult diagnostic problems.

References (40)

  • N Epstein

    Prostatic biopsy: A morphologic correlation of aspiration cytology with needle biopsy histology

    Cancer

    (1976)
  • A Kiovuniemi

    Fine needle aspiration biopsy of the breast

    Ann Clin Res

    (1976)
  • H Remky

    Tumorzellen im Kammerwasser

    Klin Monatsbl Augenheilkd

    (1961)
  • W Morgan et al.

    Metastatic carcinoma of the ciliary body simulating uveitis: Diagnosis by cytologic examination of aqueous humor

    Arch Ophthalmol

    (1970)
  • R Michels et al.

    Intraocular reticulum cell sarcoma: Diagnosis by pars plana vitrectomy

    Arch Ophthalmol

    (1975)
  • J Kennerdell et al.

    Fine needle aspiration biopsy: A report of its use in orbital tumors

    Arch Ophthalmol

    (1979)
  • F Jakobiec et al.

    The role of cytology and needle biopsies in the diagnosis of ophthalmic tumors and simulating conditions

  • F Jakobiec et al.

    Mesectodermal leiomyoma of the ciliary body: A tumor of presumed neural crest origin

    Cancer

    (1977)
  • H Shammas et al.

    False-positive results with the radioactive phosphorus test

    Arch Ophthalmol

    (1977)
  • D Minckler et al.

    Nonmelanoma ocular lesions with positive 32-P tests

  • Cited by (0)

    *

    Supported in part by a grant from the Zelda Radow Weintraub Foundation, and NIH Research Grants EY-012018 and EY-02461.

    Presented at the Second Annual Meeting of the American Society of Ophthalmic Ultrasound, Oct 23, 1978, Kansas City, MO.

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