The Level of Tryptase in Human Tears: An Indicator of Activation of Conjunctival Mast Cells
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Cited by (85)
Giant papillary conjunctivitis: A review
2020, Ocular SurfaceCitation Excerpt :It has been demonstrated that the mast cells present in the conjunctival epithelium of patients with GPC belong to a subset of mast cells (MCtc) that are known to operate within the skin and mucosa of the small intestine [5]. In patients with GPC, a significant percentage of the mast cells have degranulated, leading to elevated levels of tear tryptase [81,82]. Additionally, tear samples from affected patients also demonstrate increased levels of eosinophils and neutrophils [83].
Allergic and Immunologic Diseases of the Eye
2014, Middleton's Allergy: Principles and Practice: Eighth EditionAllergy and allergic mediators in tears
2013, Experimental Eye ResearchCitation Excerpt :Histamine levels were significantly higher in patients affected by allergic or Haemophilus influenzae-associated conjunctivitis confirming that histamine tear levels are not specifically increased exclusively in allergic conditions (Venza et al., 2004). Tear tryptase is a marker for conjunctival mast cell activation and, as such, its measurement might be useful in the diagnosis of allergic disease (Butrus et al., 1990; Magrini et al., 1996). However, it is also possible that in other forms of non-allergic conjunctivitis, non-specific activation of mast cells may occur.
The origin of tears. The aqueo-serous component in the XIX and XX centuries
2012, Ocular SurfaceOcular allergy
2010, Ocular Disease: Mechanisms and Management Expert ConsultOcular allergy
2010, Ocular Disease: Mechanisms and Management
Presented in part as a poster at the American Academy of Ophthalmology Annual Meeting, Las Vegas, October 1988.
Supported by NIH grant (AI20487) and Pharmacia (87-0697).
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Dr. Butrus is currently affiliated with the George Washington University Medical Center, Washington, DC.