Original ArticlesComparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis☆
Section snippets
Patients and methods
Patients were recruited from the uveitis clinic at St. Thomas’ Hospital, London, between January 1997 and March 1998, after Institutional Review Board/Ethics Committee approval was obtained. One hundred twenty-one eyes of 58 patients were included. Thirty-one patients had idiopathic retinal vasculitis (IRV), seven had sarcoidosis, five had intermediate uveitis, four had Behçet’s disease, three had birdshot chorioretinopathy, three had Harada’s disease, and there was one patient each with
Results
A summary of the results is shown in Table 1. Sixty-seven eyes had CME on both FFA and OCT (Figure 2). Eight eyes had CME detected by FFA but no intraretinal spaces on OCT. Five of these had subretinal fluid (SRF) on OCT, and the other three eyes all had grade 1 CME. Five other eyes had SRF on OCT that was not detected by FFA. Forty-one eyes had no CME on FFA or OCT. Overall there was good agreement between the two tests (Kendall’s τ = 0.86 for intraretinal cysts and 0.78 for all fluid, P <
Discussion
Fluorescein angiography identifies breakdown of the blood-retinal barrier. Barrier breakdown precedes fluid-related thickening at focal sites, although previous studies have shown that thickening is not always present at these sites.9 Although fluorescein leakage indicates where thickening is likely to occur in the future and where thickening, if present, is likely to be detected, it does not give a measure of thickening itself. By contrast, OCT has the potential of measuring changes in retinal
References (29)
- et al.
Complications of chronic cyclitis
Am J Ophthalmol
(1976) - et al.
Reactions following intravenous fluorescein
Am J Ophthalmol
(1971) - et al.
Nausea from fluorescein angiography
Am J Ophthalmol
(1982) - et al.
Fluorescein angiography complication survey
Ophthalmology
(1986) - et al.
Volumetric analysis of early macular edema with the Heidelberg Retina Tomograph in diabetic retinopathy
Ophthalmology
(1998) - et al.
Imaging of macular diseases with optical coherence tomography
Ophthalmology
(1995) - et al.
Optical coherence tomography of central serous chorioretinopathy
Am J Ophthalmol
(1995) - et al.
Optical coherence tomography of age-related macular degeneration and choroidal neovascularization
Ophthalmology
(1996) - et al.
Optical coherence tomography of macular holes
Ophthalmology
(1995) - et al.
Topography of diabetic macular edema with optical coherence tomography
Ophthalmology
(1998)
Characterization of epiretinal membranes using optical coherence tomography
Ophthalmology
Optical coherence tomography of macular lesions associated with optic nerve head pits
Ophthalmology
Macular thickening and visual acuity. Measurement in patients with cystoid macular edema
Ophthalmology
A perspective on the treatment of aphakic cystoid macular edema
Surv Ophthalmol
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Supported by the Lady Anne Allerton Fund and the Iris Fund for the Prevention of Blindness.