Original articleChronic central serous chorioretinopathy: photodynamic therapy☆
Section snippets
Methods
A retrospective study of our clinical practice identified four patients (seven eyes) with chronic CSCR (Table 1 and FIGURE 1, FIGURE 2, FIGURE 3). Two patients had already undergone laser photocoagulation therapy without any improvement. All four patients underwent ophthalmic examination including refraction, Snellen visual acuity testing, color photographs, fluorescein angiography, and optical coherence tomography and determined to have subretinal fluid accumulation, leakage, and serous
Results
The mean age was 58.5 years (range, 46–70 years). Three of the four were male. All patients had a history of CSCR for more than 4 years (mean, 16 years; range, 4–30 years). The initial VA ranged from 20/80 to CF 4′. Two eyes had been treated with laser photocoagulation in the past, but no patient had received laser treatment within 6 months of PDT therapy (Table 1). Photodynamic therapy with verteporfin resulted in rapid resolution of subretinal fluid and serous detachment in all five eyes of
Discussion
The pathophysiology of CSCR is not completely understood. Based on its familial occurrence and progressive, diffuse, bilateral nature, some have suggested that CSCR is an inborn disposition to develop a clinically manifest disintegration of the retinal pigment epithelium in adulthood.23 Others have linked CSCR to corticosteroids, because it has been observed in patients taking corticosteroids, Cushing syndrome, or in other conditions characterized by endogenous hypercortisolism such as type-A
Supplementary files
References (59)
- et al.
Central serous chorioretinopathy occurring in patients 60 years of age and older
Ophthalmology
(1992) - et al.
Choroidal capillary and venous congestion in central serous chorioretinopathy
Am J Ophthalmol
(1996) - et al.
Central serous chorioretinopathy and glucocorticoids
Surv Ophthalmol
(2002) - et al.
Direct and indirect laser photocoagulation of central serous chorioretinopathy
Am J Ophthalmol
(1979) - et al.
Corticosteroid-induced central serous chorioretinopathy
Jpn J Ophthalmol
(1997) - et al.
Central serous chorioretinopathy associated with inhaled or intranasal corticosteroids
Ophthalmology
(1997) - et al.
Corticosteroids and central serous chorioretinopathy
Ophthalmology
(2002) Nadolol in the treatment of central serous retinopathy
Am J Ophthalmol
(1993)- et al.
Acetazolamide for central serous chorioretinopathy
Ophthalmology
(2002) - et al.
Laser photocoagulation for persistent central serous chorioretinopathyresults of long-term follow-up
Ophthalmology
(1997)
Direct, indirect and sham laser photocoagulation in the management of central serous chorioretinopathy
Am J Ophthalmol
Ocular photodynamic therapy for serous macular detachment in the diffuse retinal pigment epitheliopathy variant of idiopathic central serous chorioretinopathy
Am J Ophthalmol
Pathogenesis of disciform detachment of the neuroepitheliumII Idiopathic central serous choriodopathy
Am J Ophthalmol
Ueber centrale reccidivirende retinitis
Graefes Arch Ophthalmol
Central serous chorioretinopathy
Stereoscopic atlas of macular diseases: diagnosis and treatment
Idiopathic central serous chorioretinopathy
Indian J Ophthalmol
Indocyanine green-mediated photothrombosis as a new technique of treatment for persistent central serous chorioretinopathy
Curr Eye Res
Long-term follow-up of central serous chorioretinopathy in 150 patients
Doc Ophthalmol
Central serous chorioretinopathy in patients over 50 years of age
Ophthalmic Surg
Experiences with non-treatment of central serous chorioretinopathy
Arch Ophthalmol
Long-term follow-up of idiopathic central serous chorioretinopathy without laser
Acta Ophthalmol Scand
Long-term follow-up of central serous chorioretinopathy
Br J Ophthalmol
Idiopathic central serous chorioretinopathy in Chinaa report of 600 cases (624 eyes) treated by acupuncture
Ophthalmic Surg
Photodynamic therapy in chronic central serous chorioretinopathy
Retina
Ring retinal pigment epithelial window defect of the macula in central serous chorioretinopathy
Retina
Indocyanine green angiography is of value for the diagnosis of chronic serous chorioretinopathy in elderly patients
Graefes Arch Clin Exp Ophthalmol
Laser treatment of diffuse retinal pigment epitheliopathy
Eur J Ophthalmol
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degenerationresults of re-treatments in a phase 1 and 2 study
Arch Ophthalmol
Cited by (153)
Long term outer retinal changes in central serous chorioretinopathy submitted to half-dose photodynamic therapy
2021, Photodiagnosis and Photodynamic TherapyComparison between the outcomes of fluorescein angiography-guided and indocyanine green angiography-guided half-time photodynamic therapy for central serous chorioretinopathy
2020, Photodiagnosis and Photodynamic TherapyFluorescein versus Indocyanine Green Angiography Guided Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
2024, Journal of Ophthalmic and Vision ResearchChanges in Aqueous Concentrations of Various Cytokines after Intravitreal Bevacizumab Injection for Chronic Central Serous Chorioretinopathy
2023, Korean Journal of Ophthalmology
- ☆
Biosketches and/or additional material at www.ajo.com