Original articlesPhotoreceptor apoptosis in human retinal detachment
Section snippets
Methods
Patients who were undergoing a vitrectomy for primary or recurrent RD repair were invited to participate in this study and were asked to sign the Massachusetts Eye & Ear Infirmary IRB-approved informed consent form. Patient demographic and clinical information was obtained and recorded. The date of the first acute retinal symptom, such as photopsias or new onset of floaters, was recorded and used to estimate the age of the retinal tear/RD.
Retinal tissue fragments (flap of horseshoe retinal tear
Results
The study group contained eight primary RD and four recurrent RD patients. Patient characteristics at the time of the initial RD are summarized in Table 1 and Table 2, respectively. Patient age ranged from 13 to 68 (average, 42.2 years).
Primary RDs were associated with trauma (three cases), giant retinal tears (three cases), choroidals after cataract surgery (one case), or were idiopathic (one case) (Table 1). Duration of RD ranged from 1 to 180 days. Recurrent RD occurred from 4 to 8 weeks
Discussion
In the present study, we report that human photoreceptor cells undergo apoptosis in response to primary and recurrent RD. The time course of photoreceptor cell apoptosis with respect to the duration of RD parallels the findings in animal models of RD, namely, apoptosis was identified within 24 hours, peaked at day 2, and dropped down to a low level after day 7. Moreover, we discovered that photoreceptor apoptosis reached a higher level in recurrent RD than in primary RD, a finding that has not
Dr. Jorge Arroyo is the Director of the Retina Service at Beth Israel Deaconess Medical Center/Harvard Medical School. His clinical interests include macular degeneration, retinal degeneration, and ocular trauma. He is the principal director of the Longwood Macular Translocation Surgery Program and is studying the benefits and risks of 360-degree macular translocation surgery for patients with severe wet AMD.
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Dr. Jorge Arroyo is the Director of the Retina Service at Beth Israel Deaconess Medical Center/Harvard Medical School. His clinical interests include macular degeneration, retinal degeneration, and ocular trauma. He is the principal director of the Longwood Macular Translocation Surgery Program and is studying the benefits and risks of 360-degree macular translocation surgery for patients with severe wet AMD.
Dong Feng Chen, M.D., Ph.D., Assistant Scientist at the Schepens Eye Research Institute; Assistant Professor at the Department of Ophthalmology, Program in Neuroscience, Harvard Medical School. Dr. Chen is a neurobiologist, particularly interested in the regeneration and repair of the retina and optic nerve. Dr. Chen’s work has been focused on the understanding of molecular mechanisms controlling retinal neural development and optic nerve regeneration.
Dr. Arroyo is a recipient of a NIH K-23 Mentored Patient-Oriented Research Career Development Award.