Original articlePredictive Factors for Progressive Optic Nerve Damage in Various Types of Chronic Open-angle Glaucoma
Section snippets
Methods
The present study is a secondary analysis of a prospectively planned investigation. Recruitment and observations were performed according to a standardized protocol. The scientific question primarily assessed was the identification of predictive factors for progression of chronic open-angle glaucoma. In the present analysis, we investigated whether various types of chronic open-angle glaucoma differ in their predictive factors for progression of glaucomatous optic nerve damage.
Results
A detailed description of follow-up, censoring, and dropouts is given in Table 4. The median follow-up time was 49 months (6 months-130 months). For 94 (18.2%) of 517 eyes and 75 (25%) of 300 patients, progression of glaucomatous optic nerve damage was detected (TABLE 2, TABLE 3). After 8 years, the Kaplan-Meier estimate for progression of glaucoma was 32.5% (CI: 23.9%-41.02%). Progression was observed in 37 (20.8%) of 178 eyes with normal intraocular pressure, in 57 (16.8%) of 339 eyes with
Discussion
The risk factors identified in the present study were predictive for morphologic progression of glaucoma. Other factors may be predictive for functional progression.
For patients with elevated intraocular pressure, predictive factors at baseline of the study for eventual progression during follow-up were advanced optic nerve damage (measured as pronounced perimetric damage and small neuroretinal rim), large β zone of parapapillary atrophy, and older age. Initial optic disk hemorrhages were not
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Supported by Deutsche Forschungsgemeinschaft DFG (SFB 539), Bonn, Germany.