Original articleMarx Line: Fluorescein Staining Line on the Inner Lid as Indicator of Meibomian Gland Function
Section snippets
Methods
The purpose of this study and the procedures to be used were presented to all of the subjects and patients, and signed informed consent was obtained from each individual. The procedures used in this study conformed to the tenets of the Declaration of Helsinki.
A total of 251 subjects (105 men and 146 women, ages 59.8 ± 20.3 years [mean ± SD]) were randomly recruited from the patients who were treated at the Department of Ophthalmology of Ehime University Hospital, Ehime, Japan. None of these
Results
Among five ophthalmologists, inconsistency of a score was settled in less than one for the ML score, and scores did not differ by two or more for all 20 images. There was 100% coincidence in 8 (40%) of 20 images, 80% coincidence in 10 (50%) of 20 images, and 60% coincidence in all 20 images.
The staining pattern of the eyelid margin with fluorescein is shown in Figure 4. A sharply defined line can be seen on the inner eyelid, and the staining with rose bengal and lissamine green B solutions was
Discussion
The concept of an evaporative type of dry eye12 has become widely recognized as a result of better understanding of the pathogenesis of MGD in recent years. The importance of assessing meibomian gland function has been emphasized because lipids secreted by these glands combine with outer layers of the tear film not only to suppress evaporation of tear fluid, but also to form a hydrophobic barrier at the lid margin to prevent loss of tears.1, 2 Focusing on the latter role, we assume that the ML
Masahiko Yamaguchi, MD, graduated from the Osaka City University School (OCU) of Medicine in 1990, and served as an ophthalmologist at the OCU Hospital from 1990 to 1995. In 1996, he joined the faculty of Ehime University School of Medicine, Department of Ophthalmology, for research on ocular surface diseases. His main area of research is in dry eye.
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Masahiko Yamaguchi, MD, graduated from the Osaka City University School (OCU) of Medicine in 1990, and served as an ophthalmologist at the OCU Hospital from 1990 to 1995. In 1996, he joined the faculty of Ehime University School of Medicine, Department of Ophthalmology, for research on ocular surface diseases. His main area of research is in dry eye.