Original articlePhotodynamic Therapy vs Limited Macular Translocation in the Management of Subfoveal Choroidal Neovascularization in Pathologic Myopia: A Two-year Study
Section snippets
Methods
This study is a retrospective comparative interventional case series of consecutive patients. We reviewed the medical records of all patients who underwent either limited macular translocation or verteporfin PDT for subfoveal CNV attributable to pathologic myopia at the University Ophthalmologic Department of Créteil (France) between January 1, 1999, and December 31, 2003.
Pathologic myopia was defined either by a refractive error of 6 diopters or more or by an axial length of 26.5 mm or more.
Results
The medical records of 66 consecutive highly myopic patients treated for subfoveal CNV were analyzed; 34 eyes underwent PDT, and 32 were operated on by the translocation technique. Preoperatively, both groups were similar for age, refractive error, and gender (Table 1). But in the PDT group, visual acuity was better, CNV had a longer duration and was larger in size, probably because criteria for translocation included a short duration of the symptoms, and a limited size of the membrane. Mean
Discussion
In this study—the first, to our knowledge, to compare PDT and limited macular translocation for subfoveal CNV attributable to pathologic myopia—translocation resulted in a better central vision recovery than PDT. Despite the retrospective nature of the study, the long follow-up provides clinically useful information. At the two-year examination, 55% of eyes in the translocation group, compared with 10% in the PDT group, had an improvement of at least 3 ETDRS lines.
In the current series, results
Agnès Glacet-Bernard, MD, is in charge of the vitreo-retinal surgery unit in the Department of Ophthalmology of the University of Créteil-Paris XII, France, chaired by Gisèle Soubrane, MD, PhD, and previously run by Gabriel Coscas, MD. After a stay in Baltimore, Maryland, she has published several reports on her experience in limited macular translocation. Dr Glacet-Bernard’s favorite topics include retinal vein occlusion and macular surgery.
References (27)
- et al.
Natural history of choroidal neovascularization in degenerative myopia
Ophthalmology
(1984) - et al.
Pathologic myopia and choroidal neovascularization
Am J Ophthalmol
(1981) - et al.
Visual function after foveal translocation with scleral shortening in patients with myopic neovascular maculopathy
Am J Ophthalmol
(1998) - et al.
Initial experience of inferior limited macular translocation for subfoveal choroidal neovascularization resulting from causes other than age-related macular degeneration
Am J Ophthalmol
(2001) - et al.
Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and degenerative myopia
Am J Ophthalmol
(2001) - et al.
Foveal translocation with scleral imbrication in patients with myopic neovascular maculopathy
Am J Ophthalmol
(2001) - et al.
Translocation of the retina for management of subfoveal choroidal neovascularization II: a preliminary report in humans
Am J Ophthalmol
(1998) - et al.
Effective nasal limited macular translocation
Am J Ophthalmol
(2001) - et al.
Severe pigment epithelial alterations in the treatment area following photodynamic therapy for classic choroidal neovascularization in young females
Am J Ophthalmol
(2004) - et al.
Photodynamic therapy with verteporfin combined with intravitreal injection of triamcinolone acetonide for choroidal neovascularization
Ophthalmology
(2005)
Surgical treatment of subfoveal neovascularization in myopia: macular translocation vs surgical removal
Am J Ophthalmol
Macular translocation with chorioscleral outfolding: 2-year results
Am J Ophthalmol
Complications associated with limited macular translocation
Am J Ophthalmol
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2012, Journal Francais d'OphtalmologieChoroidal Neovascularization in Pathologic Myopia: Recent Developments in Diagnosis and Treatment
2008, Survey of OphthalmologyCitation Excerpt :The major advantage of translocation with 360° retinotomy versus limited macular translocation seems to be the long-term preservation of improved vision.79 In addition, a 2-year comparative retrospective study demonstrated favorable results with limited macular translocation versus PDT.34 However, the Submacular Surgery Trials did not provide evidence of the efficacy of surgery in eyes with CNV due to AMD,41 and few departments are still pursuing the surgical approach.
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Agnès Glacet-Bernard, MD, is in charge of the vitreo-retinal surgery unit in the Department of Ophthalmology of the University of Créteil-Paris XII, France, chaired by Gisèle Soubrane, MD, PhD, and previously run by Gabriel Coscas, MD. After a stay in Baltimore, Maryland, she has published several reports on her experience in limited macular translocation. Dr Glacet-Bernard’s favorite topics include retinal vein occlusion and macular surgery.