Original articleOptical Coherence Tomography Reader Agreement in Neovascular Age-related Macular Degeneration
Section snippets
Methods
Data were collected from an electronic database that contained the scan grades obtained from a multicenter interventional neovascular AMD treatment trial. At each study site, the Stratus OCT with Stratus 4.0 software (Carl Zeiss Meditec) was used to obtain OCT scans according to a standardized protocol. At each patient study visit, six radial scans and a 7-mm line scan offset 5 degrees from the horizontal obtained from the study eye was transmitted to the OCT Reading Center at Duke for further
Descriptive Variables
The study comprised 132 eyes of 110 patients; 61% were left eyes. The scans showed a wide range of pathologic features, varying from a relatively normal appearing retina, RPE, and choroid to those with multiple sites of pathologic characteristics. Among all the scans used in this study, 84.8% had ME, 55.4% had cysts, 43.2% had SRF, 13.1% had VMI changes, 8.1% had ERM, 42.0% had RPEE, 6.1% had ATR, and 74.1% had CNV.
Interreader Agreement
Overall, the interreader agreement of both scan gradability and scan grades was
Discussion
In this study, a wide range of pathologic features was observed and evaluated by the readers. We found that there was excellent interreader agreement for each of the eight parameters evaluated with respect to scan gradability and scan grades for all six radial scans and the 7-mm scan offset 5 degrees from horizontal. The intrareader agreement and the agreement between initial and repeat adjudication grades was high for all categories except for ATR. The thickness measurements were performed by
Nanfei Zhang will receive an MD from Duke University School of Medicine, Durham, North Carolina in May 2007. She will begin residency training in Ophthalmology at the University of California, Davis in July 2007. Ms Zhang research endeavors were mentored by Dr Glenn Jaffe at the Duke University Eye Center, and were supported by a Howard Hughes Fellowship. After her residency, she plans to pursue fellowship training in an academic setting that combines clinical training and research.
References (18)
- et al.
Characterization of epiretinal membranes using optical coherence tomography
Ophthalmology
(1996) - et al.
Optical coherence tomography of age-related macular degeneration and choroidal neovascularization
Ophthalmology
(1996) - et al.
Optical coherence tomography to detect and manage retinal disease and glaucoma
Am J Ophthalmol
(2004) - et al.
Topography of diabetic macular edema with optical coherence tomography
Ophthalmology
(1998) - et al.
Patterns of diabetic macular edema with optical coherence tomography
Am J Ophthalmol
(1999) - et al.
Evaluation of image artifact produced by optical coherence tomography of retinal pathology
Am J Ophthalmol
(2005) - et al.
Follow-up of age-related macular degeneration patients treated by photodynamic therapy with optical coherence tomography
Graefes Arch Clin Exp Ophthalmol
(2003) MacPac: a systematic protocol for OCT12 scanning of macular pathology
J Ophthal Photogr
(2003)- et al.
Quantitative assessment of macular edema with optical coherence tomography
Arch Ophthalmol
(1995)
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2012, OphthalmologyCitation Excerpt :We previously showed that OCT images generated from 132 eyes in an interventional NVAMD trial were reproducibly interpreted in a reading center setting.16 In the present study, we observed 73% and 90% team grading agreement for IRF and SRF, respectively, comparable to the 84% to 85% and 90% to 91% inter-reader agreement for IRF and SRF, respectively, that we reported previously.16 For total thickness measurement at the foveal center in the current work, we noted a median paired difference of 0 μm between teams, which was less than the 21 to 64 μm range of inter-reader median measurement differences reported in the previous study.
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Nanfei Zhang will receive an MD from Duke University School of Medicine, Durham, North Carolina in May 2007. She will begin residency training in Ophthalmology at the University of California, Davis in July 2007. Ms Zhang research endeavors were mentored by Dr Glenn Jaffe at the Duke University Eye Center, and were supported by a Howard Hughes Fellowship. After her residency, she plans to pursue fellowship training in an academic setting that combines clinical training and research.