Original articleHost and Graft Thickness after Descemet Stripping Endothelial Keratoplasty for Fuchs Endothelial Dystrophy
Section snippets
Subjects
Patients requiring DSEK because of decreased vision caused by Fuchs endothelial dystrophy were recruited from the cornea service at Mayo Clinic, Rochester, Minnesota. Subjects were excluded if they had a filtering bleb or uncontrolled glaucoma; central corneal scarring unrelated to Fuchs dystrophy, as determined by slit-lamp biomicroscopy; or a history of herpetic keratitis, maculopathy, or optic neuropathy. All eyes were either pseudophakic or had lenticular changes requiring cataract
Subjects
Forty-four eyes of 38 patients were enrolled in the study, of which 40 eyes (34 patients) were examined through 6 months. At 12 months, data were available only for 31 eyes (27 patients) because 2 patients (2 eyes) dropped out of the study, 1 patient (1 eye) died, 1 eye (1 patient) had graft failure, and 9 eyes (9 patients) had not reached the 12-month examination yet. Mean age ± standard deviation at the time of surgery was 67 ± 10 years (range, 41 to 87 years).
Corneal Thickness
Before surgery, total corneal
Discussion
DSEK has become the preferred method for treating endothelial dysfunction, and postoperative uncorrected visual acuity and refractive error are better than they are after penetrating keratoplasty.4, 14 In contrast to penetrating keratoplasty, in which the host cornea is replaced, DSEK is an additive procedure that results in an abnormally thick cornea. In this study, in which the minimum detectable predictive relationships (from r2) were 20% at 6 months and 25% at 12 months, we found no
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Supplemental Material available at AJO.com.