Original articlePostoperative Conjunctival Inflammation After Pterygium Surgery With Amniotic Membrane Transplantation Versus Conjunctival Autograft
Section snippets
Methods
In this prospective randomized study, 42 eyes of 42 patients with primary nasal pterygium underwent surgical excision. The patients were randomized to receive either amniotic membrane transplantation (21 eyes; AMT group) or free conjunctival autograft (21 eyes; conjunctival autograft group). Furthermore, there was an additional randomization of pterygia in each group based on the morphologic features of pterygium, as described below.
Before surgery and at all visits after surgery, each patient
Results
Of 42 eyes included in this study, 12-month follow-up was completed in 39 eyes of 39 patients (22 men and 17 women) with a mean age of 45.6 ± 13.9 years (range, 19 to 83 years). These included 19 eyes in AMT group and 20 eyes in conjunctival autograft group. There were no statistically significant differences in age, gender, and grade of pterygium morphologic features before the surgery between the 2 groups (Table). Surgery was uneventful in all cases; secured attachment of both amniotic
Discussion
This prospective, randomized study showed that after pterygium surgery, conjunctival inflammation was significantly more common with AMT than with conjunctival autograft. However, with control of this inflammation and intraoperative application of MMC, similar final outcomes were achieved with both techniques. Future studies are required to evaluate the role of postoperative conjunctival inflammation in surgical outcome with other techniques of pterygium surgery.
At 1 month after pterygium
References (34)
- et al.
Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula
Ophthalmology
(1983) - et al.
Efficacy of subconjunctival 5-fluorouracil and triamcinolone injection in impending recurrent pterygium
Ophthalmology
(2006) The treatment of pterygium
Surv Ophthalmol
(2003)- et al.
Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia
Ophthalmology
(2001) - et al.
Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for Pterygium excision
Ophthalmology
(1997) - et al.
Amniotic membrane transplantation with fibrin glue for conjunctivochalasis
Am J Ophthalmol
(2007) - et al.
How does amniotic membrane work?
Ocular Surface
(2004) Effect of brief exposure of mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts
Ophthalmology
(1992)- et al.
The science of pterygia
Br J Ophthalmol
(2010) - et al.
Proliferative and migratory aptitude in pterygium
Histochem Cell Biol
(2010)