Original articleThe Effect of an Ahmed Glaucoma Valve Implant on Corneal Endothelial Cell Density in Children With Glaucoma Secondary to Uveitis
Section snippets
Methods
In this cross-sectional observational case study, we included all patients who were diagnosed with uveitis before the age of 16 years and who presented with glaucoma secondary to uveitis and received an Ahmed glaucoma valve implant at the Department of Ophthalmology at the University Medical Center, Utrecht, The Netherlands, from March 10, 2005 through December 5, 2011. Children with uveitis who were diagnosed before the age of 16 and who did not receive an Ahmed glaucoma valve implant served
Results
Eighty eyes from 42 patients were included in this study. The characteristics of the study subjects are summarized in Table 1. The Ahmed glaucoma valve group contained 28 eyes from 21 patients with an S2 implant (n = 26 eyes) or an FP8 implant (n = 2 eyes). Seven and 14 patients had bilateral and unilateral Ahmed glaucoma valve implants, respectively. The control group consisted of 52 eyes without an Ahmed glaucoma valve and included eyes with bilateral uveitis (n = 36), eyes with unilateral
Discussion
The results of this study show that previous Ahmed glaucoma valve implantation is associated with a lower corneal endothelial cell count in children with secondary glaucoma attributable to uveitis. A functioning endothelium is essential for corneal integrity, and transparency and endothelial cell loss during childhood can lead to corneal edema and, ultimately, to visual loss.15, 29 A higher rate of endothelial cell loss at a relatively young age can have negative long-term consequences for
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