Original articleRegional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma
Section snippets
Methods
This was a cross-sectional study conducted at Narayana Nethralaya, a tertiary eye care center in Bengaluru, South India, between September 2015 and March 2016. The methodology adhered to the tenets of the Declaration of Helsinki for research involving human subjects. Written informed consent was obtained from all participants and the study was approved by the Institute's Ethics Committee.
Participants of the study included control subjects and POAG patients. Control subjects were either hospital
Results
One hundred and seventy-one eyes of 102 subjects (86 eyes of 56 subjects diagnosed as normal and 85 eyes of 46 subjects diagnosed as POAG on clinical examination) underwent OCTA imaging with SDOCT. Among these, 19 eyes of 13 patients, in which the optic disc classification on stereophotographs was not glaucomatous optic neuropathy, were excluded. In addition, 20 poor quality disc scans and 25 poor quality macular scans (10 eyes had poor quality of both disc and macular scans) were also
Discussion
In the current study, a 15% reduction was found in the median inside disc vessel density in POAG eyes compared with the normal eyes. Previous studies have reported an ONH vessel density reduction of 10%–34% in glaucomatous eyes.11, 12, 15 Jia and associates also reported that the reduction in ONH vessel density was greater in the temporal part of the ONH (57%), which is devoid of the major retinal vessels, compared with the entire ONH (34%).10 In contrast to that reported by Jia and associates,
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