Cell
Volume 140, Issue 4, 19 February 2010, Pages 460-476
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Review
Lymphangiogenesis: Molecular Mechanisms and Future Promise

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The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.

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