Original articleProspective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics
Section snippets
Study Design
A prospective study of patients with infantile hemangiomas was initiated in September 2002 by members of the Hemangioma Investigator Group (HIG) at 7 U.S. academic pediatric dermatology clinics. One additional site in Spain enrolled patients, but data from that site was not used in the analysis of demographic features because U.S. National Vital Statistics System (NVSS) birth data was used for comparison. The institutional review board at each participating institution approved the study
Group Characteristics
A total of 1058 U.S. patients were enrolled in a 1-year period. Most (68%) of our patients were younger than 1 year. Ninety percent of patients were 2 years or younger. A total of 750 patients (71%) were female, and 308 patients (29%) were male. White, non-Hispanic patients comprised 68.9% of patients. African-American and Hispanic patients comprised 2.8% and 14.4% of patients, respectively. Data on gestational age were available on 1047 patients, 214 (20.4%) of whom were born prematurely
Discussion
Identifying patient characteristics associated with the development of a birth defect or “birthmark” has traditionally been performed by using formal birth defect registries. Birth defect registries are tools used to identify demographic, prenatal, and perinatal characteristics and potential risk factors that can have both clinical and scientific implications. Unfortunately, hemangiomas, though considered a type of “birthmark” have not been included in such registries because their presence at
References (11)
- et al.
Biomolecular markers and involution of hemangiomas
J Pediatr Surg
(2004) - et al.
The incidence of birthmarks in the neonate
Pediatrics
(1976) - et al.
An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS)
Prenat Diagn
(1995) - et al.
Strawberry hemangioma in preterm infants
Pediatr Dermatol
(1986) - et al.
Infantile hemangiomas: speculation on placental trophoblastic origin
Arch Dermatol
(2001)
Cited by (388)
Intramuscular deep forearm hemangioma aggravated by a traumatic event: A case report
2023, International Journal of Surgery Case ReportsLower socioeconomic status is associated with delayed access to care for infantile hemangioma: A cohort study
2023, Journal of the American Academy of DermatologyDeep-plane facelift technique for managing extensive hemifacial tumors: A retrospective study
2023, Journal of Cranio-Maxillofacial SurgeryVascular Anomalies and Other Cutaneous Congenital Defects
2023, Avery's Diseases of the NewbornPediatric dermatology and common skin conditions
2023, Encyclopedia of Child and Adolescent Health, First EditionEarly vascular embolization of large orbital and periorbital infantile capillary hemangiomas; A case report
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :Currently, there are no known causative environmental factors or mode of inheritance, although a familial transmission in an autosomal dominant fashion has been reported.3 Similar to our case, it is recognized that the incidence of hemangiomas is more common in preterm infants, and the most significant risk factor appears to be low birth weight.4 IH is known to have a female predominance and characterized by a growth phase as defined by a rapid proliferation of blood vessels for approximately 3–6 months, followed by stabilization phase, then an involution phase by the second year of life, where a replacement of the regressed vascular component by a fibrofatty tissue occurs.
Supported by the Dermatology Foundation and American Skin Association.