Original articleEffect of optic material on posterior capsule opacification in intraocular lenses with sharp-edge optics: Randomized clinical trial
Section snippets
Patients and methods
A single-center, prospective, randomized, patient- and examiner-masked, controlled trial was performed at Vienna General Hospital. All the research and measurements followed the tenets of the Declaration of Helsinki, and informed consent was provided by the patients.
Participant flow
The age of the study patients was 78±4 years (mean ± SD). Of the 53 patients (106 eyes) included in the study, 28 (56 eyes) were available for all follow-up examinations. The chart in Figure 2 shows the participant flow.
Primary outcome
The amount of PCO was analyzed from the digital retroillumination images of the 1- and 3-year follow-ups by means of the AQUA software.12 At 1 year, a mean objective PCO score of 1.6 was found for the silicone group, and a score of 1.7 for the acrylic group (scale: 0–10, P =
Discussion
The optic material, silicone and hydrophobic acrylic, had no significant impact on the main outcome variable of this study—namely, intensity of regeneratory PCO as assessed from retroillumination photographs. The long-term intensity of PCO 3 years after surgery was low for both IOL types. Only one case in each group needed Nd:YAG capsulotomy.
In the past, several authors have ascribed the low PCO rates of the Acrysof IOL to the sharp optic edge design, as seen in the animal model.15, 16 The
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Manuscript no. 240337.
The authors have no financial or proprietary interest in any of the materials or equipment mentioned in this study.