Original articleOutcome of Graft Central Thickness After Penetrating Keratoplasty
Section snippets
Study Design
We studied 856 consecutive penetrating keratoplasties carried out in 772 patients between December, 1992, and May, 2001. Eighty-four of 772 patients (9.8%) received 2 grafts in the same or contralateral eye during the study period. Because these were not independent observations, we analyzed our data, including only the first graft performed during the study period, for these 84 patients. Thus, 772 penetrating keratoplasty procedures performed in 772 patients were included in the present study.
Results
The 36- and 60-month graft survival estimates were, respectively, 77.2% and 71.0% (Fig 1). The average normal value of graft central thickness and its 95% confidence interval in successful transplants, according to postoperative time point, are shown in Figure 2 and Table 2. Graft central thickness significantly decreased between 1 and 2 weeks, between 2 weeks and 1 month, and between 1 and 3 months. It significantly increased between 12, 18, and 24 months and between 36 months and 4 years,
Discussion
Because of the high number of eyes included in this study, the normal limits of graft central thickness could be calculated at each postoperative time point after verifying that graft thickness was distributed normally in uncomplicated corneal transplants. Variability of graft central thickness was not important after the first 2 postoperative weeks, because the coefficient of variation of this measure was less than 10% at each postoperative time point.
In this series of penetrating
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2010, American Journal of OphthalmologyCitation Excerpt :Similarly, in a retrospective series, Di Pascuale and associates found that total central corneal thickness and central graft thickness stabilized by 3 to 6 months after DSEK,15 and a study by Pogorelov and associates also suggested stabilization of total central corneal thickness and graft thickness by 8 weeks after DSEK.16 These results are similar to those after penetrating keratoplasty, where corneal (graft) thickness stabilizes by 2 to 3 months.17,18 After DSEK, thicker corneas and grafts were not associated with higher forward light scatter that could degrade the retinal image.
Manuscript no. 240537.
Supported by the Paris VI University, Paris, France.
The authors have no proprietary, commercial, or financial interests in any of the products described in this study.