Original ArticleDiagnostic Ability of Optical Coherence Tomography with a Normative Database to Detect Localized Retinal Nerve Fiber Layer Defects
Section snippets
Materials and Methods
This observational, cross-sectional study included 60 eyes of 60 glaucoma patients with localized, wedge-shaped RNFL defects in red-free RNFL photographs and corresponding visual field defects. All patients were evaluated at the Seoul National University Hospital from January 2003 to December 2003. Informed consent was obtained from all subjects. All the medical procedures followed the tenets of the Declaration of Helsinki.
All subjects underwent a thorough ophthalmologic examination. This
Subject Basic Characteristics
Fifty-five eyes from 55 patients were analyzed in the study. All of the patients were Korean. The mean age ± standard deviation of the patients was 57.9±10.6 years (range, 25–78 years) and the male to female ratio was 34:21. Glaucomatous eyes had early to moderate visual field damage with mean (± standard deviation) deviation of −6.77±3.54 dB (range, −1.25 to −9.20 dB). Table 1 summarizes the demographic characteristics.
Diagnostic Ability of Optical Coherence Tomography
From 55 eyes, 71 localized RNFL defects were detected in red-free RNFL
Discussion
This study was designed with the major objective of evaluating the diagnostic ability of OCT with a normative database to detect localized RNFL defects. We confirmed that OCT with a normative database can detect the localized RNFL defects with moderate sensitivity and high specificity, and we demonstrated its good diagnostic agreement with red-free RNFL photography. Furthermore, the RNFL defects determined by OCT had an excellent topographical relationship to the RNFL defects determined by
References (25)
- et al.
Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and their progression
Am J Ophthalmol
(1991) - et al.
Intraobserver and interobserver agreement in measurement of optic disc characteristics
Ophthalmology
(1988) - et al.
Expert agreement in evaluating the optic disc for glaucoma
Ophthalmology
(1992) - et al.
Optical coherence tomography to detect and manage retinal disease and glaucoma
Am J Ophthalmol
(2004) - et al.
Diffuse and localized nerve fiber loss in glaucoma
Am J Ophthalmol
(1984) - et al.
Retinal nerve fiber layer photography in glaucoma
Ophthalmology
(1985) - et al.
Optical coherence tomography of macular holes
Ophthalmology
(1995) - et al.
Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography
Ophthalmology
(1996) - et al.
Evaluation of focal defects of the nerve fiber layer using optical coherence tomography
Ophthalmology
(1999) - et al.
Using optical imaging summary data to detect glaucoma
Ophthalmology
(2001)
The nerve fiber layer in the diagnosis of glaucoma
Arch Ophthalmol
Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage
Arch Ophthalmol
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Spectral-domain Optical Coherence Tomography in Manifest Glaucoma: Its Additive Role in Structural Diagnosis
2016, American Journal of OphthalmologyCitation Excerpt :For example, OCT reveals the RNFL thickness status in various aspects: the thickness map and deviation map can present RNFL defect itself in ways similar to RNFLP,18 the figures offer objective and quantitative RNFL thickness measurements,1 and the TSNIT graph shows both global and regional profiles of RNFL thickness. Additionally, the color-coded diagnostic classification, the usefulness of which has been well confirmed by previous studies,19–21 can indicate the extents to which suspected changes actually deviated from the normal distribution. Further studies with a different study design and setting would help in confirming other advantages of OCT in the clinical aspects, such as its usefulness in detecting progression, improving interobserver and intraobserver repeatability, and raising general ophthalmologists' diagnostic capacity to a level comparable to that of glaucoma specialists.
Establishment of a normative database for retinalnerve fiber layer thickness in a Lebanese population
2015, Journal Francais d'Ophtalmologie
Manuscript no. 2004-398.
This work was supported by the Research Program of the Ministry of Science and Technology, Seoul, Republic of Korea (grant no.: M10427020004-04L2702), and the BK21 project, Seoul, Republic of Korea.
None of the authors has a financial interest in any material or method mentioned. The authors have no financial disclosures to make regarding the subject matter presented.