Original ArticleTreatment of Anisometropic Amblyopia in Children with Refractive Correction
Section snippets
Materials and Methods
This study, supported through a cooperative agreement with the National Eye Institute of the National Institutes of Health, was conducted by the Pediatric Eye Disease Investigator Group at 34 clinical sites. The protocol and Health Insurance Portability and Accountability Act–compliant informed consent forms were approved by the respective institutional review boards. The parent or guardian of each study patient gave written informed consent. Study oversight was provided by an independent data
Results
Between February 2004 and December 2004, 84 patients with untreated anisometropic amblyopia ranging from 20/40 to 20/250 were enrolled in this study at 34 sites. The number of patients enrolled per site ranged from 1 to 9 (median = 2). The mean age of the patients at study entry was 5.2±0.9 years; 46% were female and 75% were white. Mean VA measurements at study entry were 0.60 logMAR (approximately 20/80) in the amblyopic eye and 0.04 logMAR (approximately 20/20−2) in the sound eye. Table 1
Discussion
In this prospective observational study of 84 untreated anisometropic amblyopic children 3 to <7 years old, we found that refractive correction with spectacles alone improved amblyopic eye VA an average of 2.9 lines. Visual acuity improved from baseline by ≥2 lines in 77% of the patients and by ≥3 lines in 60%. Resolution of amblyopia occurred in 27% of the cohort during the study. Additionally, amblyopia resolved in 6 of 34 (18%) patients with residual amblyopia who continued to be treated
Acknowledgment
LensCrafters provided spectacles to some patients at a reduced cost.
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Manuscript no. 2005-1116.
Supported through a cooperative agreement from the National Eye Institute, Bethesda, Maryland (grant no.: EY11751).
There are no conflicts of interest.