Original ArticleClinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging
Section snippets
Materials and Methods
Patients selected for this prospective observational case series were evaluated at the University of California—Davis Medical Center. Prior to imaging, written informed consent was obtained following the Tenets of Helsinki, and with approval of the Office of Human Research Protection of the University of California—Davis School of Medicine. Five patients were selected (Table 1), all having pathology involving the macula.
A state-of-the-art FD OCT system similar to that previously described by
Case 1
A 72-year-old male presented to the retina clinic complaining of distortion in the central vision in his left eye for several months. The clinical examination was consistent with a stage 2 full-thickness macular hole. A serial FD OCT scan is shown in Figure 2A. The scans identify the macular hole as well as the surrounding intraretinal edema and structural retinal changes. Several reconstructed OCT images are shown as well, which allow visualization of the macular hole from various perspectives
Discussion
These cases illustrate the possibility of creating a detailed and accurate retinal structural map using high-speed FD OCT. The map is created from 100 consecutive B-scans made possible by the rapid imaging speed of the system, which also limits motion artifacts. Once the map is obtained, the data can then be viewed and manipulated in different ways, allowing the clinician to view dynamically the individual B-scans that make up the map.
Cases 1 and 2 illustrate the use of this technique to image
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Manuscript no. 2005-735.
Supported by the National Eye Institute, Bethesda, Maryland (grant no.: 014743 [JSW]), and Research to Prevent Blindness, New York, New York (Jules and Doris Stein Professorship [JSW]).
The authors have no commercial or proprietary interest in products or companies mentioned in the article.