Elsevier

Ophthalmology

Volume 113, Issue 8, August 2006, Pages 1425-1431
Ophthalmology

Original Article
Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

https://doi.org/10.1016/j.ophtha.2006.03.020Get rights and content

Purpose

To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.

Design

Prospective observational case series.

Participants

Five patients with a variety of macular pathologies.

Methods

Patients were imaged with a Fourier-domain high-speed high-resolution OCT system built at our institution. A sweeping serial OCT B-scan of the macula was acquired to create a detailed retinal structural map. The data were then used to make individual clinical observations.

Results

Rapid serial OCT B-scans produced detailed macular maps for all 5 patients. Diagnoses of imaged patients included macular hole, lamellar macular hole, regressed macular hole or macular microhole, choroidal neovascular membrane (CNV) from age-related macular degeneration, and CNV from presumed ocular histoplasmosis syndrome. Reconstructed B-scans and C-scans are shown for selected patients to illustrate the additional perspectives gained by obtaining a detailed retinal map.

Conclusions

Rapid serial Fourier-domain OCT B-scanning can be used to create a detailed retinal structural map. This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.

Section snippets

Materials and Methods

Patients selected for this prospective observational case series were evaluated at the University of California—Davis Medical Center. Prior to imaging, written informed consent was obtained following the Tenets of Helsinki, and with approval of the Office of Human Research Protection of the University of California—Davis School of Medicine. Five patients were selected (Table 1), all having pathology involving the macula.

A state-of-the-art FD OCT system similar to that previously described by

Case 1

A 72-year-old male presented to the retina clinic complaining of distortion in the central vision in his left eye for several months. The clinical examination was consistent with a stage 2 full-thickness macular hole. A serial FD OCT scan is shown in Figure 2A. The scans identify the macular hole as well as the surrounding intraretinal edema and structural retinal changes. Several reconstructed OCT images are shown as well, which allow visualization of the macular hole from various perspectives

Discussion

These cases illustrate the possibility of creating a detailed and accurate retinal structural map using high-speed FD OCT. The map is created from 100 consecutive B-scans made possible by the rapid imaging speed of the system, which also limits motion artifacts. Once the map is obtained, the data can then be viewed and manipulated in different ways, allowing the clinician to view dynamically the individual B-scans that make up the map.

Cases 1 and 2 illustrate the use of this technique to image

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  • Cited by (0)

    Manuscript no. 2005-735.

    Supported by the National Eye Institute, Bethesda, Maryland (grant no.: 014743 [JSW]), and Research to Prevent Blindness, New York, New York (Jules and Doris Stein Professorship [JSW]).

    The authors have no commercial or proprietary interest in products or companies mentioned in the article.

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