Original ArticleDetection of Primary Angle Closure Using Anterior Segment Optical Coherence Tomography in Asian Eyes
Section snippets
Study Participants
Ethical approval was obtained from the ethical review board of the National University Hospital Singapore, and written informed consent was obtained from all subjects. The work was carried out in accordance with the World Medical Association’s Declaration of Helsinki. Subjects ≥40 years old were recruited from the glaucoma clinics at National University Hospital. We attempted to recruit as many patients as possible with suspected (e.g., with a shallow central or peripheral AC) or confirmed
Characteristics of Study Population
A total of 203 subjects were recruited, of whom 123 (60.6%) were female. The majority of subjects were Chinese (174 [85.7%]), Malay (9 [4.4]), and Indian (12 [5.9%]), and a small number of subjects were of other ethnic origins (8 [3.9%]). The median age of the sample was 62.5 years (range, 40–86). Diagnosis of all recruited subjects is shown in Table 1. A diagnosis of narrow angles or primary angle closure with or without glaucoma was present for 144 (70.9%) patients, some of whom had been
Discussion
Anterior segment OCT technology enables examiners to obtain detailed cross-sectional images of the ACA while avoiding contact with the globe. These images can be analyzed qualitatively. As a result, it is a quick and easily tolerated procedure for the patient. It also is likely that there is less distortion of angle morphology due to lack of globe manipulation.
In this study, AS-OCT identified almost all eyes as having closed angles that were found by gonioscopy to be closed. Using gonioscopy as
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Cited by (0)
Manuscript no. 2005-1034.
Financial support: National University of Singapore (grant nos.: R-191000007101, R-191000007112).
Technical support and loan of anterior segment optical coherence tomography machine from Carl Zeiss Meditec, Dublin, California.