Original ArticleEarly Glaucoma Detection Using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and Retinal Nerve Fiber Layer Photography
Section snippets
Patients
After obtaining the approval of the Institutional Review Board and informed consent from the patients, this study included 72 primary open-angle glaucoma (POAG) patients with early visual field defects and 48 healthy controls. One eye of each patient was selected randomly for study if both eyes satisfied the entry criteria. Each eye had a best-corrected visual acuity of 20/25 or better, a spherical-equivalent refractive error between −5 and +5 diopters, clear ocular media with no clinically
Results
Seventy-two POAG patients and 48 normal subjects were recruited. The mean ages (±standard deviation) for the glaucoma patients and controls were 37.8 (±15.6) and 38.7 (±13.6) years, respectively. Thirty-four patients (47%) in the glaucoma group and 20 patients (42%) in the control group were men. The mean mean deviation from SAP was −2.90 (±1.12) dB in glaucoma patients and −0.43 (±0.87) dB in healthy subjects, and the mean pattern standard deviation from SAP was 3.26 (±0.76) dB in glaucoma
Discussion
This study provides a comparison, using the same population, of the diagnostic accuracy of 4 instruments: the Humphrey Matrix perimetry, GDx VCC scanning laser polarimetry, Stratus OCT optical coherence tomography, and RNFL photography using HRA1. Each instrument represents the current commercially available version of a different technology for the evaluation of early glaucoma patients. In particular, the Humphrey Matrix perimeter is a new device for automated perimetry that uses FDT. The FDT
References (17)
- et al.
Visualization of localized retinal nerve fiber layer defects with the GDx with individualized and with fixed compensation of anterior segment birefringence
Ophthalmology
(2003) - et al.
Sensitivity and specificity of the StratusOCT for perimetric glaucoma
Ophthalmology
(2005) - et al.
Grading of retinal nerve fiber layer with a photographic reference set
Am J Ophthalmol
(1995) - et al.
Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography
Am J Ophthalmol
(2005) - et al.
Diagnostic accuracy of the GDx VCC for glaucoma
Ophthalmology
(2004) Number of people with glaucoma worldwide
Br J Ophthalmol
(1996)- et al.
A population-based evaluation of glaucoma screening: the Baltimore Eye Survey
Am J Epidemiol
(1991) - et al.
The Finnish evidence-based guideline for open-angle glaucoma
Acta Ophthalmol Scand
(2003)
Cited by (50)
Performance of the moorfields motion displacement test for identifying eyes with glaucoma
2014, OphthalmologyCitation Excerpt :Also, because the MMDT is a suprathreshold test, no global indices such as MD or pattern standard deviation are available for accurate quantitative analysis of defect. Our study also did not take into account the severity of glaucoma in our evaluation of its diagnostic performance, especially because motion displacement has been thought to diagnose early glaucoma even before the onset of detectable structural damage.15 Its ability to monitor progressive changes in VFs as well as to characterize the severity of field loss remains to be determined.
Assessment of visual function in glaucoma: A report by the American academy of ophthalmology
2011, OphthalmologyCitation Excerpt :Hong et al42 first compared normal subjects with glaucoma subjects with early visual field loss (MD no worse than –6 dB) on 30-2 SITA standard SAP perimetry using the Matrix and determined that the number of points with a P value <0.05 was the best discriminating parameter. The same group subsequently compared the Matrix with GDx VCC (Carl Zeiss Meditec), Stratus OCT, and RNFL photography using the Heidelberg Retina Angiograph 1 (Heidelberg Engineering GmbH) in a similar group of subjects.43 Using the number of points with P<0.05 on the pattern deviation plot, the AUC for the Matrix was 0.99, corresponding to a sensitivity of 100% and a specificity of 92% when a cutoff of 5 abnormal points was used.
Sita-standard perimetry has better performance than FDT2 matrix perimetry for detecting glaucomatous progression
2018, British Journal of OphthalmologyComparison of frequency doubling and flicker defined form perimetry in early glaucoma
2016, Graefe's Archive for Clinical and Experimental OphthalmologyImaging in glaucoma care pathways in the UK
2016, Journal of Visual Communication in Medicine
Manuscript no. 2005-915.
The authors do not have any financial conflict of interest regarding the article’s subject matter.