Original ArticleRetinal Nerve Fiber Layer Thickness and Visual Sensitivity Using Scanning Laser Polarimetry with Variable and Enhanced Corneal Compensation
Section snippets
Participants
One eye each from 127 glaucoma patients or glaucoma suspects (criteria below) enrolled in the University of California, San Diego–based longitudinal Diagnostic Innovations in Glaucoma Study was studied. All participant eyes had good quality GDx-VCC and GDx-ECC images obtained on the same day. A reliable visual field (VF) test within 6 months also was required.
Each study participant underwent a comprehensive ophthalmologic evaluation including review of medical history, best-corrected visual
Retinal Nerve Fiber Layer Thickness Differences
Significant differences in RNFL thickness measured using VCC compared with ECC were found in the temporal, superotemporal and nasal circumpapillary sectors. In all significant cases, ECC measurements were lower than VCC measurements. Differences were greatest in the temporal RNFL (Δ RNFL thickness = 10.49 μm) followed by the superotemporal RNFL (Δ RNFL thickness = 5.23 μm) and the nasal RNFL (Δ RNFL thickness = 3.04 μm; Table 1). In addition, TSS was significantly different for VCC (mean, 85.4;
Discussion
This study showed that measurements of RNFL thickness differed between SLP using VCC and ECC, but only in the temporal, superotemporal, and nasal circumpapillary regions. In addition, although structure–function associations were generally stronger using ECC compared with VCC, this difference was only significant between inferotemporal RNFL measurements and superonasal VF sensitivity measurements. The second finding was somewhat surprising because we assumed that increased strength of
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Manuscript no. 2006-805.
Supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/Ministério da Educação e Cultura, Brasília, Brazil, and the National Institutes of Health, Bethesda, Maryland (grant nos. EY11008, EY08208). Participant retention incentive grants in the form of glaucoma medication at no cost: Alcon Laboratories Inc., Allergan, Pfizer Inc., and SANTEN Inc.
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Drs Medeiros, Zangwill, Sample, and Weinreb received research funding and/or research materials at no cost from Carl Zeiss Meditec. Drs Zangwill and Weinreb received research funding and/or research materials at no cost from Heidelberg Engineering. Dr Zangwill received gifts in kind, honoraria, or travel reimbursement valued at >$1000 in the last 12 months from Heidelberg Engineering. Dr Weinreb received gifts in kind, honoraria, or travel reimbursement valued at >$1000 in the last 12 months from Carl Zeiss Meditec and Heidelberg Engineering.