Original articlePrevalence of Primary Angle-Closure Disease in an Urban South Indian Population and Comparison with a Rural Population: The Chennai Glaucoma Study
Section snippets
Materials and Methods
The CGS was carried out between June 2001 and May 2004. This study was approved by an institutional ethics review board and performed in accordance with the tenets of the Declaration of Helsinki for research involving human subjects. The CGS’s methods and design are described in detail elsewhere.11
In summary, a sample size of 4758 was arrived at assuming an 85% response rate, for an assumed 3% population prevalence of glaucoma, with a relative precision of 25% and a design effect of 2. Four
Results
Of the 4800 enumerated, 3850 subjects participated in the study (response rate, 80.2%). There were 1710 (44.4%) males and 2140 (55.6%) females. The mean age of the study population was 54.8±10.6 years (range, 40–103). Two thousand five hundred thirty-two subjects had normal and reliable suprathreshold VF test results in both eyes on frequency-doubling perimetry. The distribution of VCDR and IOP for the normal population was derived from the right eye measurements of these subjects. The mean
Discussion
Quigley and Broman estimate that, by 2010, 87% of angle-closure glaucoma (ACG) cases will be Asian.19 The currently reported prevalence rates are highest for Chinese, intermediate among Indians, and lowest for Japanese.19 There seems to be wide variation in the reported prevalence of PACG within India. The prevalence of PACG in southern India ranges from 0.5% to 4.3%,6, 7, 8, 9 whereas the reported prevalence of PACG in eastern India was only 0.23%.20
In this study, we report the prevalence
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Manuscript no. 2006-1286.
Financial support: Chennai Willingdon Corporate Foundation, Chennai, India.