Original articleMorphologic Changes in Acute Central Serous Chorioretinopathy Evaluated by Fourier-Domain Optical Coherence Tomography
Section snippets
Materials and Methods
We prospectively studied 21 eyes of consecutive 20 patients (18 men, 2 women) with acute CSC using the FD OCT system (RTVue-100, Optovue, Fremont, CA) between June 2006 and May 2007 at Osaka University Medical School, Osaka, Japan. This study was approved by the institutional review board, and informed consent was obtained from all patients.
A diagnosis of acute CSC was made based on the presence of a serous detachment of the neurosensory retina, focal dye leakage on FA, and the duration of
Patient Characteristics
The profiles of the patients are shown in Table 1 (available at http://aaojournal.org). The mean age of the 20 patients was 47.4 years (range, 32–65). The duration of symptoms ranged from 1 to 86 days (mean, 16.0). Four eyes had recurrent disease, and the other 2 had CSC history in the fellow eye. The mean BCVA at baseline was 0.84 (range, 0.2–1.5). Nineteen eyes had 1 point of focal leakage and 2 eyes showed 2 points of leakage; 17 leakage points in 16 eyes (74%) had an inkblot pattern, and 6
Discussion
The primary pathology of acute CSC is thought to begin with disruption of the choroidal circulation. The RPE then decompensates and allows exudation from the choroidal vasculature to pass into the subretinal space.1, 2, 3, 4, 5, 6, 7 These hypotheses are based on FA and indocyanine green angiography findings, and precise morphologic correlations have not been observed.
The development of OCT has provided a better understanding of the mechanism in CSC, especially the abnormalities in the RPE
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Manuscript no. 2007-883.
Financial Disclosure(s): Dr Tano is a consultant for Optovue, Inc.