Original articleThe Singapore 5-Fluorouracil Trabeculectomy Study: Effects on Intraocular Pressure Control and Disease Progression at 3 Years
Section snippets
Patients and Methods
Participants were enrolled into a prospective, randomized, double-blind, placebo-controlled trial studying the role intraoperative 5-FU in glaucoma filtration surgery. Subjects were recruited from the Singapore National Eye Centre and the National University Hospital, Singapore. Written, informed consent was obtained from all participants. The study had the approval of the Ethical Review Committee of Singapore National Eye Centre and was carried out in accordance with the tenets of the
Results
A total of 288 participants were recruited. Of these, 45 could not be randomized and were therefore excluded. The main reasons for nonrecruitment were inability to perform visual fields tests and being unsuitable for surgery owing to illness. The remaining 243 patients were randomized to receive placebo or 5-FU during trabeculectomy surgery. The demographic and clinical features of the 2 treatment groups at baseline are summarized in Table 2, Table 3.
By postoperative year 1, 1 patient was lost
Discussion
The long-term outcome of primary trabeculectomy with antimetabolites in Asian eyes has not as yet been reported in detail. A retrospective study from Hong Kong looked at the surgical outcome of trabeculectomy with MMC in Chinese patients. The authors reported a reduction of IOP of <21 mmHg in 73.7% of patients with a mean follow-up of 29 months.23 Similar trabeculectomy survival rates in 5-FU augmented trabeculectomies were found in another retrospective study conducted in Singapore. Wong et al
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Manuscript no. 2008-323.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Medical Research Council of Singapore (NMRC/0044/1998) and Singapore National Eye Centre. Professor Khaw, Dr Foster and Dr Minassian received funding from the Medical Research Council (UK) (Grant number G9330070) and the NIHR Biomedical Research Centre.