Original articleTear Cytokine Profile in Medicated Glaucoma Patients: Effect of Monocyte Chemoattractant Protein 1 on Early Posttrabeculectomy Outcome
Section snippets
Study Population
This study was conducted in accordance with the Declaration of Helsinki and after approval from the local institutional review board at the Singapore Eye Research Institute. A total of 61 patients with glaucoma and 29 nonglaucomatous subjects were recruited from glaucoma and general eye clinics, respectively, at the Singapore National Eye Centre. Informed written consent pertaining to the donation and storage of human fluid samples was obtained from all subjects.
The glaucoma subtypes, primary
Results
Patients were treated with antiglaucoma medications for periods ranging from 1 to 165 months at the time of surgery. Fifty-three patients were taking a prostaglandin analog (Travoprost: Travatan, Alcon, Fort Worth, TX; Latanoprost: Xalatan, Pfizer, New York, NY; Bimatoprost: Lumigan, Allergan Inc., Irvine, CA), 42 were taking the β-blocker Timolol (Timoptic: Merck, Whitehouse Station, NJ), 13 were taking the α-agonist Brimonidine (Alphagan: Allergan Inc., Irvine, CA), and 4 were taking a
Discussion
Bleb failure resulting from excessive subconjunctival scarring is the most common cause of failure in glaucoma filtration surgery.4 Such failure can occur as early as within the first year after surgery and is characterized by inflammation and an increase in the number of active fibroblasts.6 Various studies spanning the last 2 decades have shown that topical glaucoma medication changes the conjunctiva cell profile, inducing a proinflammatory state that can be detected through
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Manuscript no. 2009-1175.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Peng T. Khaw - Financial Support - Promedior, Allergan, Pfizer, Bausch & Lomb, Merck, Daniolabs, and Astra Zeneca.
None of the other authors have any financial interests to disclose.
Supported by the National Medical Research Council of Singapore, Singapore, Republic of Singapore (NMRC:R551/39/2007); and Singapore National Eye Centre, Singapore, Republic of Singapore. Dr Khaw is supported by the National Institute of Health Research Biomedical Research Centre for Ophthalmology, London, United Kingdom.