Original articleChoroidal Thickness in Polypoidal Choroidal Vasculopathy and Exudative Age-related Macular Degeneration
Section snippets
Materials and Methods
We evaluated patients with PCV and exudative AMD accompanied with choroidal neovascularization who were examined at the Department of Ophthalmology at Samsung Medical Center from October 2009 to March 2010. Institutional review board approval (institutional review board file number 2010-04-033) was obtained for this study. According to the findings of the pilot study, the difference in choroidal thickness is expected to be 30 μm for eyes with early AMD and 50 μm for eyes with exudative AMD,
Results
A total of 87 subjects (47 male and 40 female) with a mean (± standard deviation [SD]) age of 69.9±8.4 years were involved in this study. The study ultimately included 25 eyes of 21 patients with PCV, 14 uninvolved fellow eyes of patients with PCV, 30 eyes of 30 patients with exudative AMD, 17 eyes of 16 patients with early AMD, and 20 age-matched normal eyes. Among 21 patients with PCV, 6 (28.6%) evidenced PCV involvement in both eyes. Among those 6 patients, 2 fellow eyes were excluded
Discussion
This study disclosed choroidal thinning in AMD, and, by contrast, marked choroidal thickening in PCV, when compared with choroidal thickness of age-matched normal eyes. Choroidal thickness in patients with early AMD also tended to be thinner than that of normal eyes. As far as we are aware, this is the first study reporting on choroidal thickness in those disorders. Because of difficulty in recruitment, eyes presenting dry AMD were not included in this study. The disorder has been known to be
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Manuscript no. 2010-798.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.