Original articleSquamous Carcinoma and Dysplasia of the Conjunctiva and Cornea: An Analysis of 101 Cases
Section snippets
Patients and Methods
This study adhered to the tenets of the Declaration of Helsinki of 1975, as revised in 2000, and the Health Insurance Portability and Accountability Act of 1996 and was approved by the institutional review board of The New York Eye Cancer Center. The study was a retrospective case review of 101 eyes of 99 consecutive patients who were diagnosed pathologically with conjunctival squamous dysplasia, conjunctival carcinoma in situ, or SCC. Selection also required access to patient medical records,
Results
One hundred one eyes from 99 patients with an age range of 37 to 96 years (median, 71 years) were studied. Lesions were present on the right eye in 49 patients and on the left in 48 patients, and 2 patients had bilateral disease. Sixty-seven percent of patients (n = 67/99) were male.
Clinical appearance evaluation showed that 42.6% (n = 43/101) of SCC cases were focal nodular tumors, 51.5% (n = 52/101) were diffuse tumors, and 5.9% (n = 6/101) were pigmented tumors. Multifocality was seen in
Discussion
Significant predictors for tumor recurrence were the size of the tumor (>5 mm), extension of the corneal involvement (>2 mm), local invasiveness, pathologic characteristics, higher AJCC T stage of the disease at presentation, and inadequate primary surgical treatment before referral. Recurrence was not correlated significantly to age, gender, laterality, clinical appearance, or focality of the tumor at presentation. In line with previous reports, a slight male predominance (67.7% were males)
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Manuscript no. 2011-722.
Dr. Yousef received fellowships from The Eye Cancer Foundation, Inc, New York, New York (http://eyecancerfoundation.net), and the International Council of Ophthalmology Switzerland and San Francisco, California.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.