Original articleDiagnostic Ability of a Linear Discriminant Function for Spectral-Domain Optical Coherence Tomography in Patients with Multiple Sclerosis
Section snippets
Materials and Methods
The design of the study followed the Declaration of Helsinki Principles. The study protocol was approved by the Clinical Research Ethics Committee of Aragon (Zaragoza, Spain), and informed written consent was obtained from all participants.
Results
A total of 115 eyes from 115 patients with relapsing-remitting MS were examined. A previous acute optic neuritis attack was reported for 35 eyes (30%), whereas 80 eyes (70%) were studied from patients with no history of optic neuritis. The duration of the MS ranged from 6 months to 40 years with a median of 9.3 years since diagnosis. The ages of patients ranged from 20 to 62 years with a mean of 41.2 years (Table 1). The ratio of women to men was 2:1 (76 female, 39 male). Mean intraocular
Discussion
Previous studies have reported the sensitivity and specificity of OCT for discriminating between healthy and MS eyes.18, 19 In addition, some studies have attempted to increase the diagnostic ability of OCT for some pathologies using learning classifiers,9, 20, 21 yet the sensitivity and specificity of OCT to diagnose MS have not improved. We were unable to find published studies aimed at calculating an LDF solely on the basis of RNFL parameters measured with OCT in patients with MS. The
Conclusions
Although we were unable to find other combinations of RNFL parameters with better diagnostic ability, other statistical analyses could provide alternative formulas that would increase the diagnostic performance of the Spectralis OCT. The AUC of the proposed LDF was not significantly different from the temporal and the temporal inferior sector thicknesses, but the sensitivity values were higher for the LDF at a high fixed specificity. Also, the lowest negative LR was found for the LDF, and these
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Manuscript no. 2011-1704.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.