Original articleChoroidal Volume Variations with Age, Axial Length, and Sex in Healthy Subjects: A Three-Dimensional Analysis
Section snippets
Study Population
Starting in July 2011, all patients undergoing SD-OCT scans at the Jacobs Retina Center at Shiley Eye Center, University of California San Diego (La Jolla, CA) underwent choroidal imaging as part of their evaluation. A raster scan of the macula using an SD-OCT device in EDI mode (Heidelberg Spectralis HRA2; Heidelberg Engineering, Carlsbad, CA) was used to study the choroid. The raster scan required approximately 30 seconds of additional time and was therefore incorporated into the standard
Results
A total of 176 eyes of 114 healthy subjects (51 men and 63 women), with a mean age of 50 years (range, 14–89 years), were included in the study. Ethnic distribution included 75 Caucasian subjects, 20 Asian subjects, 18 Hispanic subjects, and 1 black subject. A total of 160 eyes were phakic, and 16 eyes were pseudophakic. The best-corrected visual acuity ranged from 20/63 to 20/20 (Snellen equivalent). Axial length measurement was available for 146 of 176 eyes (83%). The mean axial length was
Discussion
In this study, 3-dimensional visualization of the choroid of the macular area in a large sample of healthy eyes was performed using EDI SD-OCT and allowed a comprehensive analysis of the choroidal anatomy. Manual segmentation of the choroidal borders was performed following a well-reproducible method described in a previous report by our group.34 The volume of the analyzed choroid was automatically calculated by the built-in software of the SD-OCT.
So far, no previous report has provided in vivo
References (41)
- et al.
Choroidal neovascularization
Am J Ophthalmol
(2004) - et al.
Temporal relationship of choroidal blood flow and thickness changes during recovery from form deprivation myopia in chicks
Exp Eye Res
(2002) - et al.
Enhanced depth imaging spectral-domain optical coherence tomography
Am J Ophthalmol
(2008) - et al.
A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
Am J Ophthalmol
(2009) Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration
Am J Ophthalmol
(2009)- et al.
Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes
Am J Ophthalmol
(2009) - et al.
Subfoveal choroidal thickness after treatment of central serous chorioretinopathy
Ophthalmology
(2010) - et al.
Enhanced depth imaging optical coherence tomography of the sclera in dome-shaped macula
Am J Ophthalmol
(2011) - et al.
Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
Ophthalmology
(2011) - et al.
Choroidal thickness and volume mapping by a six radial scan protocol on spectral-domain optical coherence tomography
Ophthalmology
(2012)
Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study
Ophthalmology
Metabolic dependence of photoreceptors on the choroid in the normal and detached retina
Invest Ophthalmol Vis Sci
Polypoidal choroidal vasculopathy and treatments
Curr Opin Ophthalmol
Photodynamic therapy for variant central serous chorioretinopathy: efficacy and side effects
Ophthalmologica
Vogt-Koyanagi-Harada disease
Int Ophthalmol Clin
Measurement of subfoveal choroidal thickness using spectral domain optical coherence tomography
Ophthalmic Surg Lasers Imaging
Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography
Am J Ophthalmol
Choroidal thickness in healthy Chinese subjects
Invest Ophthalmol Vis Sci
Repeatability of manual subfoveal choroidal thickness measurements in healthy subjects using the technique of enhanced depth imaging optical coherence tomography
Invest Ophthalmol Vis Sci
Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography
J Biophotonics
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Manuscript no. 2012-378.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by National Institutes of Health Grants R01EY007366 and R01EY018589 (W.R.F.), R01EY016323 (D.U.B.), and R01EY020617 (L.C.). RPB Incorporated and unrestricted funds from Jacobs Retina Center. The funding organizations had no role in the design or conduct of this research.