Original articleObstructive Sleep Apnea and Increased Risk of Glaucoma: A Population-Based Matched-Cohort Study
Section snippets
Database
The data used in this study were sourced from the Longitudinal Health Insurance Database 2000 (LHID2000), which is derived from the Taiwan National Health Insurance (NHI) program and maintained by the Taiwan National Health Research Institute, includes the registration files and original claims data for the reimbursement of 1 000 000 beneficiaries under the NHI program. These 1 000 000 beneficiaries were randomly selected from the year 2000 Registry of Beneficiaries (n = 23.72 million) of the
Results
Table 1 shows the distribution of demographic characteristics and comorbidities between the study cohort and the comparison cohort. Of the total of 6072 subjects, the mean age was 56.0 years (standard deviation, 11.9) and 60% were male. After matching for gender, age group, and urbanization level, subjects with OSA had a higher prevalence of the following comorbidities than comparison subjects: hypertension (P<0.001), diabetes (P<0.001), coronary heart disease (P<0.001), hyperlipidemia (P
Discussion
We found that patients with OSA were independently associated with a 1.67 times increased risk of OAG diagnosis within the first 5 years after their diagnosis, after adjusting for monthly income, diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, renal disease, hypothyroidism, and the number of outpatient visits for ophthalmologic care during the follow-up period.
Several previous studies exploring the link between OSA and OAG were cross-sectional or retrospective in nature
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Manuscript no. 2012-1417.
Financial Disclosures: The authors have no proprietary or commercial interest in any of the materials discussed in this article.