Original articleReduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma
Section snippets
Methods
This hospital-based observational study included patients with POAG. Criteria for the diagnosis of POAG were an IOP measurement of more than 21 mmHg, an open and normal-appearing anterior chamber angle on gonioscopy, glaucomatous abnormalities of the optic nerve head, and visual field defects. Criteria for inclusion into the study were a visual field loss with mean deviation (MD) in the better-seeing eye of more than −6 dB, a preserved central visual field at least within the central 5°, a
Results
The study group included 13 POAG patients (11 men and 2 women) with a mean age of 47±7 years. The mean perimetric defect was −19.5±6.3 dB in the tested eye and −15.4±9.3 dB in the fellow eye, and the mean retinal nerve fiber layer thickness was 62.5±6.5 μm in the tested eye and 68.7±10.4 μm in the fellow eye. Intraocular pressure measured in the tested eye and the fellow eye of the patients was 17.1±4.9 and 15.3±3.7 mmHg, respectively. Eight patients had undergone glaucoma surgery, 3 patients
Discussion
In our study of patients with POAG and without systemic cardiovascular or central nervous system disorders, we investigated the hemodynamic characteristics of the PCA, the main vessel supplying the visual pathway posterior to the lateral geniculate ganglion. We observed disturbed hemodynamics in the PCA of POAG patients at baseline, after visual stimulation, and under hyperventilation. The glaucoma patients showed a significantly higher vasoresistance in the ipsilateral PCA at baseline, a
Acknowledgment
The authors thank Professor Jost B. Jonas for his tremendous help in revising the English language of this manuscript.
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Supported by the Postdoctoral Science Foundation of China (grant no.: 20100480170); the National Nature Science Foundation of China (grant no.: 81100661); and Key Lab Open Foundation of Capital Medical University, Beijing, China (grant no.: 2010YKSJ04).
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S.Z. and Y.X. contributed equally as first authors.