Original articleRandomized Trial of Multifocal Intraocular Lenses versus Monovision after Bilateral Cataract Surgery
Section snippets
Study Design
The study was conducted at 2 hospitals: Moorfields Eye Hospital, London, United Kingdom, and King's College Hospital, London, United Kingdom. The protocol was approved by the Collaborative Research Ethics Committee. Informed written consent was obtained from all patients according to the tenets of the Declaration of Helsinki. The study was a randomized controlled trial and has been registered at www.controlled-trials.com/ISRCTN37400841 (accessed May 12, 2013).
Enrollment of Participants, Data Collection, and Follow-up
Patients with bilateral cataract
Results
Between April 28, 2007, and August 25, 2010, 212 patients were enrolled. One patient became unwell immediately after randomization and never underwent surgery as part of the trial. The 2 arms of the study were similar in age (68.7±12.0 years for monovision vs. 67.0±11.2 for multifocal) and sex (female 57.5% for monovision vs. female 55.7% for multifocal).
The flow of patients through the trial is shown in Figure 1. Six patients had IOLs implanted that they were not randomized to receive. Five
Discussion
This study shows that patients undergoing bilateral cataract surgery randomized to bilateral implantation with the Tecnis ZM900 multifocal IOL achieve higher spectacle independence than those randomized to receive the Akreos AO IOL with lens power selection adjusted to achieve low monovision. Patient satisfaction was high in both arms, but dysphotopsia scores were higher in patients randomized to multifocal IOL implantation. Glare in particular was reported more frequently by patients receiving
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Funded by an unrestricted grant from Abbott Medical Optics and Bausch & Lomb. The funding organizations had no role in the design or conduct of this research. This work was supported in part by the UK National Institute for Health Research Biomedical Research Centre in Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology.
A full listing of the Moorfields IOL Study Group is available at http://aaojournal.org.
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A full listing of the Moorfields IOL Study Group is available at http://aaojournal.org.