Original articleAssociation between Baseline Iris Thickness and Prophylactic Laser Peripheral Iridotomy Outcomes in Primary Angle-Closure Suspects
Section snippets
Methods
Approval for this prospective study was obtained from the University of California, San Francisco, Committee on Human Research. The study was carried out in accordance with the tenets of the Declaration of Helsinki. Caucasian and Chinese subjects were consecutively recruited from the University of California, San Francisco, general ophthalmology and glaucoma clinics between April 2008 and December 2012. All enrolled subjects provided written informed consent. Inclusion criteria for subject
Results
A total of 74 consecutively enrolled Caucasian and Chinese patients received LPI and agreed to participate in the study during the specified time period. Among them, 22 subjects were excluded from the study for 1 or more of the following reasons: (1) Five subjects could not or did not complete the ASOCT examination; (2) 13 subjects had poor ASOCT imaging quality (evaluated on the basis of corneal reflection, continuity of anterior segment structures, motion artifacts, and indeterminate scleral
Discussion
This study evaluated the association between baseline measurements of iris thickness at 3 positions (IT750, IT2000, and ITM) and the change in anterior segment biometric parameters (ICURV, TISA500, and TISA750) after prophylactic LPI in nonglaucomatous subjects with anatomically narrow angles. Our results showed significant decrease in ICURV and increases in TISA500 and TISA750 after LPI. These findings are consistent with previous imaging studies using ASOCT to examine the morphology of the
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Long-term Changes in Anterior Segment Characteristics of Eyes With Different Primary Angle-Closure Mechanisms
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2018, American Journal of OphthalmologyAnterior Segment Dimensions Following Laser Iridotomy in Acute Primary Angle Closure and Fellow Eyes
2018, American Journal of OphthalmologyCitation Excerpt :In the adjusted model, assigning to the fellow eye did not reach significance, revealing that angle width and iris curvature before LPI can predict LPI efficacy in eyes with APAC and their fellow eyes. Iris thickness, iris curvature, baseline angle opening, and LV are among factors that have been demonstrated to affect the anatomic LPI efficacy.18,22,24,33 In a study by Huang and associates,33 greater preoperative iris curvature and smaller preoperative iris area were predictive of angle widening.
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by National Institutes of Health National Eye Institute EY002162 Core Grant for Vision Research, Research to Prevent Blindness, and That Man May See, Inc.