Original articleAge-Related Macular Degeneration and Risk of Degenerative Dementia among the Elderly in Taiwan: A Population-Based Cohort Study
Section snippets
Database
The NHIRD, a large and comprehensive nationwide population-based database published annually by Taiwan National Health Research Institute in an electronically encrypted form, contains all the original claims data from the Taiwan National Health Insurance (NHI) program. This mandatory, single-payer social health insurance system has been in operation since 1995 and currently has more than 22 million enrollees, representing approximately 99% of the Taiwanese population. Among the subsets of the
Results
The final analysis included 4993 patients with AMD and 24 965 matched controls (Fig 1). Of these patients with AMD, only 540 (10.8%) cases had claims for exudative form (ICD-9-CM codes 362.52). We matched patients with AMD and the controls in terms of age (mean age, 74.5 years), gender (53.0% male), and the year of index date. The distributions of demographic characteristics, comorbidities, and number of clinical visits for these 2 cohorts are shown in Table 1. Patients with AMD were more
Discussion
In the current retrospective cohort study, our results show that patients with AMD had a 1.44-fold greater risk of a subsequent AD or senile dementia than the matched controls after adjusting for baseline comorbidities and number of clinical visits. Likewise, we found comparable results when analyzing only patients in the nonexudative AMD subtype. However, the difference in the incidence of AD or senile dementia between patients with exudative AMD and the matched controls was outside the
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2023, American Journal of OphthalmologyCitation Excerpt :The main population comprised Asians,16,24,26 Whites,13,14,15,25 and African Americans14 based on the included studies or databases. The methods adopted for ascertaining dementia or AD included medical records,25 research diagnostic criteria,13-14,27 and International Classification of Diseases (ICD) codes.15-16,24 Supplementary Table S3 provides the adjusted covariates of each study.
Supplemental material is available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported in part by research grants from RD 2014-024 from National Yang-Ming University Hospital, Yilan, Taiwan; V99B1-011, V99C1-125, and V100B-013 from Taipei Veterans General Hospital, Taipei, Taiwan; CI-97-13 and CI-98-16 from the Yen Tjing Ling Medical Foundation, Taipei, Taiwan; MOST-2015-Free Style Excellent Project (NCTU-NYMU-UCSD), and NSC 100-2314-B-075-055 from the National Science Council. The sponsor or funding organization had no role in the design or conduct of this research.
Author Contributions:
Conception and design: Tsai, Chen, Leu
Data collection: Tsai, Huang, Leu
Analysis and interpretation: Tsai, Chen, Huang, Yuan, Leu
Obtained funding: Not applicable
Overall responsibility: Tsai, Chen, Leu