Original articleThe Ahmed Versus Baerveldt Study: Five-Year Treatment Outcomes
Section snippets
Methods
The AVB study methodology is described in detail in our baseline article17 and will be summarized in the current article. Institutional review board approval was obtained at each clinical center, and the study protocol is registered on www.ClinicalTrials.gov (NCT00940823).
Baseline Characteristics
A total of 238 patients were recruited and randomized: 124 (52%) to the Ahmed group and 114 (48%) to the Baerveldt group. The baseline characteristics of the study group were similar and are presented in Table 1. Mean patient age was 66 years old with uncontrolled disease as evidenced by a mean preoperative IOP of 31 mmHg on 3 classes of glaucoma medications. Many patients had failed trabeculectomy with antimetabolite (37%) or had high-risk disease, including neovascular (21%) or uveitic (10%)
Discussion
The AVB study is an international, multicenter, randomized trial comparing the 2 most frequently used aqueous shunts. Enrolled patients had uncontrolled glaucoma despite maximum tolerated medical therapy, with 37% of patients having failed trabeculectomy with mitomycin C and 31% of patients having neovascular or uveitic glaucoma. Aqueous shunts are being increasingly used in this patient population.12 An IOP target of ≤18 mmHg was selected on the basis of Advanced Glaucoma Intervention Study
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Supplemental material is available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have made the following disclosure(s): P.J.H.: Personal fees – Abbott Medical Optics.
I.I.K.A.: Personal fees – Abbott Medical Optics and New World Medical.
The AVB study is supported by a research grant from the Glaucoma Research Society of Canada, Toronto, Canada (I.I.K.A., P.G.C.) and a departmental challenge grant from the Research to Prevent Blindness, Inc, New York, New York (J.C.T.). Our research funding sponsors had no role in the design or conduct of the study.
Author Contributions:
Conception and design: Christakis, Kalenak, Tsai, Zurakowski, Kammer, Harasymowycz, Mura, Cantor, Ahmed
Data collection: Christakis, Kalenak, Tsai, Zurakowski, Kammer, Harasymowycz, Mura, Cantor, Ahmed
Analysis and interpretation: Christakis, Kalenak, Tsai, Zurakowski, Kammer, Harasymowycz, Mura, Cantor, Ahmed
Obtained funding: Not applicable
Overall responsibility: Christakis, Kalenak, Tsai, Zurakowski, Kammer, Harasymowycz, Mura, Cantor, Ahmed