Abstract
In the present review, the methodologies and clinical applications of the visual evoked potentials (VEPs) after photostress, will be described. Photostress induces transient VEP changes consisting of an increase in response latency and a decrease in amplitude. When serial VEP recordings are obtained at discrete time intervals (i.e., every 20 s) after bleaching, the recovery of VEP waveform can be evaluated. The time needed for the VEP to recover to the pre-bleach, baseline status (recovery time after photostress) ranges in normal subjects between 68 and 78 s. Patients with different pathologies (maculopathies, ocular hypertension and glaucoma, diabetes with or without retinopathy, multiple sclerosis with optic neuritis) showed an abnormal response after photostress (higher increase in latency and decrease in amplitude and longer recovery time) with respect to age-matched controls. Our results indicate that the VEPs after photostress represent an objective, although not specific, index of the dynamic properties of macular performance after exposure to intense light stimulation.
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Weleber RG, Eisner A. Retinal function and physiological studies. In: Newsome DA ed. Retinal dystrophies and degenerations. New York: Raven Press, 1988: 21–69.
Parisi V, Falsini B. Electrophysiological evaluation of the macular cone system: focal electroretinography and VEP after photostress. Semin Ophthalmol 1998; 13: 178–88.
Lovasik JV. An electrophysiological investigation of the macular photostress test. Invest Ophthalmol Vis Sci 1983; 24: 437–41.
Franchi A, Magni R, Lodigiani R, Cordella M. VEP pattern after photostress: an index of macular function. Graefe's Arch Clin Exp Ophthalmol 1987; 225: 291-4.
Baillart JP. L'examen functionel de la macula. Rapport à la Société d'Ophthalmologie de Paris. Bull Soc Ophthalmol Fr 1954; 4(Suppl): I–LXVII.
Severin SL, Tour R, Kershaw H. Macular function and the photostress test. Arch Ophthalmol 1967; 77: 163–7.
Franzone M, Brunetti GM, Coggi G, Peronzini S. Test del tempo di recupero maculare dopo abbagliamento: attendibilità dell'esame. Bol Oculistica 1985; 64(Suppl 11/12): 141–51.
Wu G, Weiter JJ, Santos S, Ginsburg L, Villalobos R. The macular photostress test in diabetic retinopathy and age related macular degeneration. Arch Ophthalmol 1990; 108: 1556–8.
Sandberg MA, Gaudio AR. Slow photostress recovery and disease severity in age-related macular degeneration. Retina 1995; 15: 407–12.
Littlewood R, Johnson G, House P. Vision testing in atrophic macular degeneration. Aust N Z J Ophthalmol 1996; 24: 47–51.
Midena E, Degli Angeli C, Blarzino MC, Valenti M, Segato T. Macular function impairment in eyes with early age-related macular degeneration. Invest Ophthalmol Vis Sci. 1997; 38: 469–77.
Zingirian M, Polizzi A, Grillo N. The macular recovery test after photostress in normal and diabetic subjects. Acta Diabetol Lat. 1985; 22: 169–72.
Mosci C, Polizzi A, Grillo N, Capris P, Zingirian M. Ottimizzazione del test del recupero maculare nello studio dei soggetti diabetici. Bol Oculistica 1986; 65: 347–56.
Sherman MD, Henkind P. Photostress recovery in chronic open angle glaucoma. Br J Ophthalmol 1988; 72: 641–5.
Parisi V, Bucci MG. Visual evoked potentials after photostress in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 1992; 33: 436–42.
Parisi V, Uccioli L, Monticone G, Parisi L, Menzinger G, Bucci MG. Visual evoked potentials after photostress in insulin-dependent diabetic patients with or without retinopathy. Graefe's Arch Clin Exp Ophthalmol 1994; 232: 193–8.
Parisi V, Uccioli L, Monticone G, Parisi L, Pernini C, Durola L, Neuschuler R, Menzinger G, Bucci MG. Visual Evoked Potentials ‘after photostress’ in newly diagnosed insulin-dependent patients. Graefe's Arch Clin Exp Ophthalmol 1995; 233: 601–4.
Uccioli L, Parisi V, Monticone G, Parisi L, Durola L, Pernini C, Neuschuler R, Bucci MG, Menzinger G. Electrophysiological study of visual pathways in IDDM newly diagnosed patients. Diabetologia 1995; 38: 804–8.
Parisi V, Uccioli L, Monticone G, Parisi L, Ippoliti D, Manni GL, Menzinger G, Bucci MG. Electrophysiological assessment of visual function in IDDM patients. Electroencephalogr Clin Neurophysiol 1997; 104: 171–9.
Bucci MG, Parisi V, Giannini R, Rossini PM. Recordings of visual evoked potentials after photostress in artificially increased intraocular pressure. Clin Vision Sci 1991; 6: 431–6.
Parisi V, Pierelli F, Restuccia R, Spadaro M, Parisi L, Colacino G, Bucci MG. Impaired VEP after photostress response in multiple sclerosis patients previously affected by optic neuritis. Electroencephalogr Clin Neurophysiol 1998; 108: 73–9.
Bianchini E, Franchi A, Manni R, Villani LG, Cordella M, Botta GC. Carotid occlusive disease: an electrophysiological macular investigation. J Cardiovasc Surg. 1987; 28: 524–7.
Franchi A, Groppi E, Taratufolo G, Villani LG. Improvement of VEP photostress recovery test in patients with stenosis of the carotid artery and thrombosis of the internal contralateral carotid, after endarterectomy. Int Angiol. 1990; 9: 25–8.
Parisi V, Uccioli L, Parisi L, Colacino G, Manni GL, Menzinger G, Bucci MG. Neural conduction in the visual pathways in newly diagnosed IDDMpatient. Electroencephalogr Clin Neurophysiol 1998; 108: 490–6.
Sadun AA. Distinguishing between clinical impairments due to optic nerve or macular disease. MPS 1990; 13: 79–84.
Campos EC, Enoch JM, Fitzgerald CR, Benedetto MD. A simple psychophysical technique provides early diagnosis in optic neuritis. Doc Ophthalmol 1980; 15: 325–35.
Falsini B, Colotto A, Porciatti V, Buzzonetti L, Coppè A, De Luca LA. Macular flickerand pattern ERGs are differently affected in ocular hypertension and glaucoma. Clin Vis Sci 1991; 6: 422–9.
Falsini B, Bardocci A, Porciatti V, Bolzani R, Piccardi M. Macular dysfunction in multiple sclerosis revealed by steady-state flicker and pattern ERGs. Electroencephalogr Clin Neurophysiol. 1992; 83: 53–9.
Ghirlanda G, Di Leo MAS, Caputo S, Falsini B, Porciatti V, Marietti G, Greco AV. Detection of inner retina dysfunction by steady-state focal electroretinogram pattern and flicker in early IDDM. Diabetes 1991; 40: 1122–7.
Palmowski AM, Fung W, Bearse MA Jr, Sutter EE. Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram. Invest Ophthalmol Vis Sci 1997; 38: 2586–96.
Van Lith GHM, Van Marle GW, Van Dowmak GTM. Variation in latency times of visually evoked cortical potentials. Br J Ophthalmol 1978; 62: 220–2.
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Parisi, V. Electrophysiological evaluation of the macular cone adaptation: VEP after photostress. Doc Ophthalmol 102, 251–262 (2001). https://doi.org/10.1023/A:1017514616801
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DOI: https://doi.org/10.1023/A:1017514616801