Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Eyeing a new route along an old pathway

Little is known about molecular mechanisms responsible for the development of glaucoma, the leading cause of irreversible blindness worldwide. A new study suggests that glaucoma pathogenesis involves an endothelial leukocyte cell-adhesion molecule that is implicated in the development of vascular diseases (pages 304-309).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic diagram of eye structures involved in aqueous humor dynamics.

Bob Crimi

References

  1. Wang, N., Chintala, S.K., Fini, M.E. & Schuman, J.S. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nature Med. 7, 304–309 (2001).

    Article  CAS  Google Scholar 

  2. Craig, J.E. & Mackey, D.A. Glaucoma genetics: where are we? Where will we go? Curr. Opin. Ophthalmol. 10, 126–134 (1999).

    Article  CAS  Google Scholar 

  3. Colllins, T. et al. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9, 899–909 (1995).

    Article  Google Scholar 

  4. Coca-Prados, M., Escribano, J. & Ortego, J. Differential gene expression in the human ciliary epithelium. Prog. Retin. Eye Res. 18, 403–429 (1999).

    Article  CAS  Google Scholar 

  5. Gonzalez, P., Epstein, D.L. & Borras, T. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. Invest. Ophthalmol. Vis. Sci. 41, 3678–3693 (2000).

    CAS  PubMed  Google Scholar 

  6. Yoshida, M. et al. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. J. Cell Biol. 133, 445–455 (1996).

    Article  CAS  Google Scholar 

  7. Kaplanski, G. et al. A novel role for E- and P-selectins: shape control of endothelial cell monolayers. J. Cell Sci. 107, 2449–2457 (1994).

    Google Scholar 

  8. Tian, B., Geiger, B., Epstein, D.L. & Kaufman, P.L. Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest. Ophthalmol. Vis. Sci. 41, 619–623 (2000).

    CAS  PubMed  Google Scholar 

  9. Steely, H.T., English-Wright, S. L. & Clark, A.F. The similarity of protein expression in trabecular meshwork and lamina cribrosa: Implications for glaucoma. Exp. Eye Res. 70, 17–30 (2000).

    Article  CAS  Google Scholar 

  10. Yan, X., Tezel, G., Wax, M.B. & Edward, D.P. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch. Ophthalmol. 118, 666–673 (2000).

    Article  CAS  Google Scholar 

  11. Yuan, L. & Neufeld, A.H. Tumor necrosis factor-α: A potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 32, 42–50 (2000).

    Article  CAS  Google Scholar 

  12. Neufeld, A.H., Sawada, A. & Becker, B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc. Natl. Acad. Sci. USA 96, 9944–9948 (1999).

    Article  CAS  Google Scholar 

  13. Hu, Y., Kiely, J.M., Szente, B.E., Rosenzweig, A. & Gimbrone, M.A. Jr. E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells. J. Immunol. 165, 2142–2148 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tomarev, S. Eyeing a new route along an old pathway. Nat Med 7, 294–295 (2001). https://doi.org/10.1038/85432

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/85432

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing