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Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

Nature Immunology volume 13, pages 439–447 (2012)Cite this article

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Abstract

Lymphocyte activation must be tightly regulated to ensure sufficient immunity to pathogens and prevent autoimmunity. Protein tyrosine phosphatases (PTPs) serve critical roles in this regulation by controlling the functions of key receptors and intracellular signaling molecules in lymphocytes. In some cases, PTPs inhibit lymphocyte activation, whereas in others they promote it. Here we discuss recent progress in elucidating the roles and mechanisms of action of PTPs in lymphocyte activation. We also review the accumulating evidence that genetic alterations in PTPs are involved in human autoimmunity.

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Figure 1: The main activating receptors involved in lymphocyte activation.
Figure 2: Regulation of Src family kinases by CD45 and CD148 in lymphocytes.
Figure 3: Regulation of Src family kinases by PTPN22.
Figure 4: Control of NK cell activation by SHP-1.

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Acknowledgements

Supported by the Canadian Institutes of Health Research (A.V.), the Canadian Cancer Society Research Institute (A.V.), The Canada Research Chairs program (A.V.) and the Howard Hughes Medical Institute (A.V.).

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  1. Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada

    Inmoo Rhee & André Veillette

  2. Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Québec, Canada

    Inmoo Rhee & André Veillette

  3. Department of Medicine, University of Montréal, Montréal, Québec, Canada

    André Veillette

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Rhee, I., Veillette, A. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat Immunol 13, 439–447 (2012). https://doi.org/10.1038/ni.2246

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